Discrepancy between Thermodynamic and Kinetic Stabilities of the tert-Butanol Hydrates and Its Implication for Obtaining Pharmaceutical Powders by Freeze-Drying | Sciact - CRIS-system of Boreskov Institute of Catalysis

Discrepancy between Thermodynamic and Kinetic Stabilities of the tert-Butanol Hydrates and Its Implication for Obtaining Pharmaceutical Powders by Freeze-Drying Full article

Journal

Chemical Communications
ISSN: 1359-7345 , E-ISSN: 1364-548X

Output data

Year: 2019, Volume: 55, Number: 29, Pages: 4262-4265 Pages count : 4 DOI: 10.1039/C9CC00397E

Tags

BUTYL ALCOHOL; PROCESS PERFORMANCE; QUALITY ATTRIBUTES; COSOLVENT SYSTEMS; ICE NUCLEATION; PHASE-DIAGRAM; LYOPHILIZATION; DESIGN

Authors

Ogienko A.G. ^1,2 , Stoporev A.S. ^1,2,3 , Ogienko A.A. ^1,4 , Mel’gunov M.S. ^2,5 , Adamova T.P. ¹ , Yunoshev A.S. ^2,6 , Manakov A.Yu. ^1,2 , Boldyreva E.V. ^2,5

Affiliations

1	Nikolaev Institute of Inorganic Chemistry SB RAS, 630090 Novosibirsk, Russia
2	Novosibirsk State University, 630090 Novosibirsk, Russia
3	Department of Physical and Colloid Chemistry, Gubkin University, 119991, Moscow, Russia
4	Institute of Molecular and Cellular Biology SB RAS, 630090 Novosibirsk, Russia
5	Boreskov Institute of Catalysis SB RAS, 630090 Novosibirsk, Russia
6	Lavrentiev Institute of Hydrodynamics SB RAS, 630090 Novosibirsk, Russia.

Funding (2)

1	Ministry of Science and Higher Education of the Russian Federation	0239-2019-0003
2	Russian Foundation for Basic Research	17-03-00784 (АААА-А17-117040710138-5)

The tert-butanol (TBA) – water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).

Ogienko A.G. , Stoporev A.S. , Ogienko A.A. , Mel’gunov M.S. , Adamova T.P. , Yunoshev A.S. , Manakov A.Y. , Boldyreva E.V.
Discrepancy between Thermodynamic and Kinetic Stabilities of the tert-Butanol Hydrates and Its Implication for Obtaining Pharmaceutical Powders by Freeze-Drying
Chemical Communications. 2019. V.55. N29. P.4262-4265. DOI: 10.1039/C9CC00397E WOS Scopus РИНЦ AN OpenAlex

Submitted:	Jan 16, 2019
Accepted:	Mar 18, 2019
Published online:	Mar 19, 2019
Published print:	Apr 14, 2019

Web of science:	WOS:000467970400026
Scopus:	2-s2.0-85064038707
Elibrary:	38680252
Chemical Abstracts:	2019:515681
OpenAlex:	W2922947576

DB	Citing
Scopus	8
Web of science	8
Elibrary	7
OpenAlex	8