Abstract: Herein, I illustrate analytically how the global diffusion limitations can influence the first phase of the protein-corona formation at nanoparticles under conditions of intravascular injection. In particular, the concentrations of proteins near the boundaries of the injection region are shown to be comparable with those far from the region. In contrast, the concentrations of proteins inside the injection region may be dramatically smaller than those outside, and the ratio of these two concentrations for proteins of different size may be much higher, by a few orders of magnitude, for smaller proteins. These differences in the spatial distribution of proteins are expected to play a key role in the Vroman effect at the onset of the protein-corona formation.

Cite: Zhdanov V.P.
Global Diffusion Limitations During the Initial Phase of the Formation of a Protein Corona Around Nanoparticles
Journal of Biological Physics. 2019. V.45. N2. P.173–181. DOI: 10.1007/s10867-019-09522-8 WOS Scopus РИНЦ AN PMID OpenAlex

Files: Full text from publisher

Dates:

Submitted:	Aug 22, 2018
Accepted:	Feb 20, 2019
Published online:	Mar 20, 2019
Published print:	Jun 1, 2019

Identifiers:

Web of science:	WOS:000470336300004
Scopus:	2-s2.0-85063155355
Elibrary:	38672578
Chemical Abstracts:	2020:537127
PMID:	30895408
OpenAlex:	W2924999656

Citing:

DB	Citing
Scopus	1
Web of science	1
Elibrary	1
OpenAlex	2

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