High Resolution Quantitative Tracing and Modulation of Nanoparticles' Nose-to-Brain Transmission | Sciact - CRIS-система Института катализа

High Resolution Quantitative Tracing and Modulation of Nanoparticles' Nose-to-Brain Transmission Научная публикация

Конференция

4th International Conference on Metamaterials and Nanophotonics
15-19 июл. 2019 , St. Petersburg

Журнал

Journal of Physics: Conference Series
ISSN: 1742-6588 , E-ISSN: 1742-6596

Вых. Данные

Год: 2020, Том: 1461, Номер: 1, Номер статьи : 012141, Страниц : 5 DOI: 10.1088/1742-6596/1461/1/012141

Ключевые слова

iron oxide gold nanoparticle nasal drug delivery system

Авторы

Romashchenko A.V. ^1,2 , Petrovski D.V. ¹ , Trotsky S.Yu. ³ , Morozova K.N. ^1,6 , Illarionova N.B. ¹ , Zhukova M.V. ¹ , Kiseleva E.V. ^1,6 , Sharapova M.B. ¹ , Sherbakov I.S. ¹ , Rakshun Y.V. ⁴ , Kuper K.E. ⁴ , Gerlinskaya L.A. ¹ , Lin F.H. ⁵ , Moshkin Y.M. ¹ , Moshkin M.P. ¹

Организации

1	The Federal Research Center Institute of Cytology and Genetics, SB RAS, Academician Lavrentiev Avenue, 10, 630090, Novosibirsk, Russia
2	The Federal Research Center The Institute of Computational Technologies, SB RAS, Academician Lavrentiev Avenue, 6, 630090, Novosibirsk, Russia
3	G. K. Boreskov Institute of Catalysis, SB RAS, Academician Lavrentiev Avenue, 5, 630090, Novosibirsk, Russia
4	The Federal Research Center Budker Institute of Nuclear Physics, SB RAS, Academician Lavrentiev Avenue, 11, 630090, Novosibirsk, Russia
5	Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan
6	Novosibirsk State University, st. Pirogova, 2, 630090, Novosibirsk, Russia

Информация о финансировании (1)

Российский научный фонд

17-74-10081 (АААА-А17-117101820006-1)

A large number of studies in animal models have shown that nanoscale particles of organic or inorganic nature, as well as many types of viruses, are able to transport from the nasal cavity to the brain bypassing the blood-brain barrier (BBB). In recent years, the ability of nanoparticles (NPs) in the form of elemental particular materials, such as iron (II) oxide, manganese oxide, carbon and gold, to reach deep structures of the brain after being administered into the nasal cavity was well established. Nevertheless, information on brain localization, accumulation dynamics and delivery routes of NPs after their intranasal administration is fragmentary and contradictory. The answers to these questions are of exceptional importance both for the determination of the most probable targets for the toxic effect of nanoscale air pollutants, and for solving the problems of targeted delivery of NPs acting as an independent therapeutic agents or as an nanocarriers for drugs.

Romashchenko A.V. , Petrovski D.V. , Trotsky S.Y. , Morozova K.N. , Illarionova N.B. , Zhukova M.V. , Kiseleva E.V. , Sharapova M.B. , Sherbakov I.S. , Rakshun Y.V. , Kuper K.E. , Gerlinskaya L.A. , Lin F.H. , Moshkin Y.M. , Moshkin M.P.
High Resolution Quantitative Tracing and Modulation of Nanoparticles' Nose-to-Brain Transmission

Journal of Physics: Conference Series. 2020. V.1461. N1. 012141 :1-5. DOI: 10.1088/1742-6596/1461/1/012141 WOS Scopus РИНЦ CAPlusCA OpenAlex

Полный текст от издателя

Поступила в редакцию:	24 дек. 2019 г.
Опубликована в печати:	23 апр. 2020 г.
Опубликована online:	23 апр. 2020 г.

Web of science:	WOS:000546469400139
Scopus:	2-s2.0-85084124401
РИНЦ:	43279192
Chemical Abstracts:	2020:1925850
Chemical Abstracts (print):	174:21341
OpenAlex:	W3017715946

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