High Resolution Quantitative Tracing and Modulation of Nanoparticles' Nose-to-Brain Transmission | Sciact - CRIS-system of Boreskov Institute of Catalysis

High Resolution Quantitative Tracing and Modulation of Nanoparticles' Nose-to-Brain Transmission Full article

Conference

4th International Conference on Metamaterials and Nanophotonics
15-19 Jul 2019 , St. Petersburg

Journal

Journal of Physics: Conference Series
ISSN: 1742-6588 , E-ISSN: 1742-6596

Output data

Year: 2020, Volume: 1461, Number: 1, Article number : 012141, Pages count : 5 DOI: 10.1088/1742-6596/1461/1/012141

Tags

iron oxide gold nanoparticle nasal drug delivery system

Authors

Romashchenko A.V. ^1,2 , Petrovski D.V. ¹ , Trotsky S.Yu. ³ , Morozova K.N. ^1,6 , Illarionova N.B. ¹ , Zhukova M.V. ¹ , Kiseleva E.V. ^1,6 , Sharapova M.B. ¹ , Sherbakov I.S. ¹ , Rakshun Y.V. ⁴ , Kuper K.E. ⁴ , Gerlinskaya L.A. ¹ , Lin F.H. ⁵ , Moshkin Y.M. ¹ , Moshkin M.P. ¹

Affiliations

1	The Federal Research Center Institute of Cytology and Genetics, SB RAS, Academician Lavrentiev Avenue, 10, 630090, Novosibirsk, Russia
2	The Federal Research Center The Institute of Computational Technologies, SB RAS, Academician Lavrentiev Avenue, 6, 630090, Novosibirsk, Russia
3	G. K. Boreskov Institute of Catalysis, SB RAS, Academician Lavrentiev Avenue, 5, 630090, Novosibirsk, Russia
4	The Federal Research Center Budker Institute of Nuclear Physics, SB RAS, Academician Lavrentiev Avenue, 11, 630090, Novosibirsk, Russia
5	Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan
6	Novosibirsk State University, st. Pirogova, 2, 630090, Novosibirsk, Russia

Funding (1)

Russian Science Foundation

17-74-10081 (АААА-А17-117101820006-1)

A large number of studies in animal models have shown that nanoscale particles of organic or inorganic nature, as well as many types of viruses, are able to transport from the nasal cavity to the brain bypassing the blood-brain barrier (BBB). In recent years, the ability of nanoparticles (NPs) in the form of elemental particular materials, such as iron (II) oxide, manganese oxide, carbon and gold, to reach deep structures of the brain after being administered into the nasal cavity was well established. Nevertheless, information on brain localization, accumulation dynamics and delivery routes of NPs after their intranasal administration is fragmentary and contradictory. The answers to these questions are of exceptional importance both for the determination of the most probable targets for the toxic effect of nanoscale air pollutants, and for solving the problems of targeted delivery of NPs acting as an independent therapeutic agents or as an nanocarriers for drugs.

Romashchenko A.V. , Petrovski D.V. , Trotsky S.Y. , Morozova K.N. , Illarionova N.B. , Zhukova M.V. , Kiseleva E.V. , Sharapova M.B. , Sherbakov I.S. , Rakshun Y.V. , Kuper K.E. , Gerlinskaya L.A. , Lin F.H. , Moshkin Y.M. , Moshkin M.P.
High Resolution Quantitative Tracing and Modulation of Nanoparticles' Nose-to-Brain Transmission

Journal of Physics: Conference Series. 2020. V.1461. N1. 012141 :1-5. DOI: 10.1088/1742-6596/1461/1/012141 WOS Scopus РИНЦ ANCAN OpenAlex

Full text from publisher

Submitted:	Dec 24, 2019
Published print:	Apr 23, 2020
Published online:	Apr 23, 2020

Web of science:	WOS:000546469400139
Scopus:	2-s2.0-85084124401
Elibrary:	43279192
Chemical Abstracts:	2020:1925850
Chemical Abstracts (print):	174:21341
OpenAlex:	W3017715946

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