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Accumulation Pattern of Intranasally Installed Metal Oxide Nanoparticles in the Mouse Olfactory Bulb Научная публикация

Конференция 4th International Conference on Metamaterials and Nanophotonics
15-19 июл. 2019 , St. Petersburg
Журнал Journal of Physics: Conference Series
ISSN: 1742-6588 , E-ISSN: 1742-6596
Вых. Данные Год: 2020, Том: 1461, Номер: 1, Номер статьи : 012140, Страниц : 5 DOI: 10.1088/1742-6596/1461/1/012140
Ключевые слова manganese titanium oxide nanoparticle intranasal delivery olfactory bulb
Авторы Petrovski D.V. 1 , Romashchenko A.V. 1,2 , Trotsky S.Yu. 3 , Morozova K.N. 1 , Kiseleva E.V. 1 , Sharapova M.B. 1 , Rakshun Y.V. 4 , Kuper K.E. 4 , Moshkin Y.M. 1 , Moshkin M.P. 1
Организации
1 The Federal Research Center Institute of Cytology and Genetics, SB RAS, Academician Lavrentiev Avenue, 10, 630090, Novosibirsk, Russia
2 The Federal Research Center The Institute of Computational Technologies, SB RAS, Academician Lavrentiev Avenue, 6, 630090, Novosibirsk, Russia
3 G. K. Boreskov Institute of Catalysis, SB RAS, Academician Lavrentiev Avenue, 5, 630090, Novosibirsk, Russia
4 The Federal Research Center Budker Institute of Nuclear Physics, SB RAS, Academician Lavrentiev Avenue, 11, 630090, Novosibirsk, Russia

Информация о финансировании (2)

1 Российский научный фонд 17-74-10081 (АААА-А17-117101820006-1)
2 Российский фонд фундаментальных исследований 18-04-00472 (АААА-А18-118020290008-3)

Реферат: Certain nanomaterials of organic or inorganic nature, as well as some viruses, are capable of translocating from the nasal cavity into the brain bypassing blood-brain barrier (BBB). For example, nanoparticles (NP), such as carbon, gold, metal (manganese, iron, titanium) oxides, etc., could reach deep brain structures after administration into the nasal cavity. Upon intranasal administration, NPs accumulate mainly in the structures of olfactory system, especially in olfactory bulbs and anterior olfactory nuclei. On the one hand, NPs are attractive "platform" for the development of non-invasive nose-to-brain drug delivery systems, and magnetic resonance imaging (MRI)- or radiocontrast agents for neuroimaging. But, on the other hand, potential neurotoxicity of air dispersed nano-pollutants raises significant concerns as a risk factor for dementia and other neurol. disorders. Thus, it is crucial to detail accumulation patterns of nose-to-brain transport of NPs both qual. and quant. In this study, we investigated the distribution of NPs through the layers of mouse olfactory bulb after their intranasal administration. To address this, we prepared neg. charged manganese oxide nanoparticles (MnFe2O4-NPs) and platinum oxide particles (PtO-Ps), which were efficiently transmitted from the nasal cavity into the brain. Because the intensity of T1 -weighted MRI signal of MnFe2O4-NPs strongly correlated with Mn concentration in brain structures, this allowed high-resolution quant. tracking of NP's brain trafficking with 11.7 T MRI. To estimate the extrapolation of the obtained distribution patterns, we intranasally administered PtO-Ps, available for detection in the brain tissues by transmission electron microscopy (TEM) and micro-X-ray fluorescent anal. (micro-RFA).
Библиографическая ссылка: Petrovski D.V. , Romashchenko A.V. , Trotsky S.Y. , Morozova K.N. , Kiseleva E.V. , Sharapova M.B. , Rakshun Y.V. , Kuper K.E. , Moshkin Y.M. , Moshkin M.P.
Accumulation Pattern of Intranasally Installed Metal Oxide Nanoparticles in the Mouse Olfactory Bulb
Journal of Physics: Conference Series. 2020. V.1461. N1. 012140 :1-5. DOI: 10.1088/1742-6596/1461/1/012140 WOS Scopus РИНЦ CAPlusCA OpenAlex
Файлы: Полный текст от издателя
Даты:
Поступила в редакцию: 24 дек. 2019 г.
Опубликована в печати: 23 апр. 2020 г.
Опубликована online: 23 апр. 2020 г.
Идентификаторы БД:
Web of science: WOS:000546469400138
Scopus: 2-s2.0-85084138194
РИНЦ: 43303768
Chemical Abstracts: 2020:1925899
Chemical Abstracts (print): 174:21023
OpenAlex: W3019951761
Цитирование в БД: Пока нет цитирований
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