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Accumulation Pattern of Intranasally Installed Metal Oxide Nanoparticles in the Mouse Olfactory Bulb Full article

Conference 4th International Conference on Metamaterials and Nanophotonics
15-19 Jul 2019 , St. Petersburg
Journal Journal of Physics: Conference Series
ISSN: 1742-6588 , E-ISSN: 1742-6596
Output data Year: 2020, Volume: 1461, Number: 1, Article number : 012140, Pages count : 5 DOI: 10.1088/1742-6596/1461/1/012140
Tags manganese titanium oxide nanoparticle intranasal delivery olfactory bulb
Authors Petrovski D.V. 1 , Romashchenko A.V. 1,2 , Trotsky S.Yu. 3 , Morozova K.N. 1 , Kiseleva E.V. 1 , Sharapova M.B. 1 , Rakshun Y.V. 4 , Kuper K.E. 4 , Moshkin Y.M. 1 , Moshkin M.P. 1
Affiliations
1 The Federal Research Center Institute of Cytology and Genetics, SB RAS, Academician Lavrentiev Avenue, 10, 630090, Novosibirsk, Russia
2 The Federal Research Center The Institute of Computational Technologies, SB RAS, Academician Lavrentiev Avenue, 6, 630090, Novosibirsk, Russia
3 G. K. Boreskov Institute of Catalysis, SB RAS, Academician Lavrentiev Avenue, 5, 630090, Novosibirsk, Russia
4 The Federal Research Center Budker Institute of Nuclear Physics, SB RAS, Academician Lavrentiev Avenue, 11, 630090, Novosibirsk, Russia

Funding (2)

1 Russian Science Foundation 17-74-10081 (АААА-А17-117101820006-1)
2 Russian Foundation for Basic Research 18-04-00472 (АААА-А18-118020290008-3)

Abstract: Certain nanomaterials of organic or inorganic nature, as well as some viruses, are capable of translocating from the nasal cavity into the brain bypassing blood-brain barrier (BBB). For example, nanoparticles (NP), such as carbon, gold, metal (manganese, iron, titanium) oxides, etc., could reach deep brain structures after administration into the nasal cavity. Upon intranasal administration, NPs accumulate mainly in the structures of olfactory system, especially in olfactory bulbs and anterior olfactory nuclei. On the one hand, NPs are attractive "platform" for the development of non-invasive nose-to-brain drug delivery systems, and magnetic resonance imaging (MRI)- or radiocontrast agents for neuroimaging. But, on the other hand, potential neurotoxicity of air dispersed nano-pollutants raises significant concerns as a risk factor for dementia and other neurol. disorders. Thus, it is crucial to detail accumulation patterns of nose-to-brain transport of NPs both qual. and quant. In this study, we investigated the distribution of NPs through the layers of mouse olfactory bulb after their intranasal administration. To address this, we prepared neg. charged manganese oxide nanoparticles (MnFe2O4-NPs) and platinum oxide particles (PtO-Ps), which were efficiently transmitted from the nasal cavity into the brain. Because the intensity of T1 -weighted MRI signal of MnFe2O4-NPs strongly correlated with Mn concentration in brain structures, this allowed high-resolution quant. tracking of NP's brain trafficking with 11.7 T MRI. To estimate the extrapolation of the obtained distribution patterns, we intranasally administered PtO-Ps, available for detection in the brain tissues by transmission electron microscopy (TEM) and micro-X-ray fluorescent anal. (micro-RFA).
Cite: Petrovski D.V. , Romashchenko A.V. , Trotsky S.Y. , Morozova K.N. , Kiseleva E.V. , Sharapova M.B. , Rakshun Y.V. , Kuper K.E. , Moshkin Y.M. , Moshkin M.P.
Accumulation Pattern of Intranasally Installed Metal Oxide Nanoparticles in the Mouse Olfactory Bulb
Journal of Physics: Conference Series. 2020. V.1461. N1. 012140 :1-5. DOI: 10.1088/1742-6596/1461/1/012140 WOS Scopus РИНЦ ANCAN OpenAlex
Files: Full text from publisher
Dates:
Submitted: Dec 24, 2019
Published print: Apr 23, 2020
Published online: Apr 23, 2020
Identifiers:
Web of science: WOS:000546469400138
Scopus: 2-s2.0-85084138194
Elibrary: 43303768
Chemical Abstracts: 2020:1925899
Chemical Abstracts (print): 174:21023
OpenAlex: W3019951761
Citing: Пока нет цитирований
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