Parahydrogen‐Induced Polarization of Diethyl Ether Anesthetic | Sciact - CRIS-система Института катализа

Parahydrogen‐Induced Polarization of Diethyl Ether Anesthetic Научная публикация

Журнал

Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765

Вых. Данные

Год: 2020, Том: 26, Номер: 60, Страницы: 13621-13626 Страниц : 7 DOI: 10.1002/chem.202002528, 10.1002/chem.202086063

Ключевые слова

anesthetic; hydrogen; hyperpolarization; imaging agents; neurochemistry; parahydrogen

Авторы

Ariyasingha Nuwandi M. ¹ , Joalland Baptiste ¹ , Younes Hassan R. ¹ , Salnikov Oleg G. ^2,3,4 , Chukanov Nikita V. ^3,4 , Kovtunov Kirill V. ^3,4 , Kovtunova Larisa M. ^2,3,4 , Bukhtiyarov Valerii I. ^2,4 , Koptyug Igor V. ^3,4 , Gelovani Juri G. ^1,5 , Chekmenev Eduard Y. ^1,6

Организации

1	Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202 (USA)
2	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., 630090 Novosibirsk (Russia)
3	International Tomography Center SB RAS, 3A Institutskaya St., 630090 Novosibirsk (Russia)
4	Department of Natural Sciences, Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk (Russia)
5	United Arab Emirates University, Al Ain (United Arab Emirates)
6	Russian Academy of Sciences (RAS),14 Leninskiy Prospekt, 119991 Moscow (Russia)

Информация о финансировании (7)

1	National Science Foundation	CHE-1904780
2	United States Department of Defense	W81XWH-15-1-0271
3	Российский фонд фундаментальных исследований	17-54-33037
4	Российский фонд фундаментальных исследований	19-53-12013 (АААА-А19-119040990042-7)
5	Российский фонд фундаментальных исследований	19-33-60045
6	Федеральное агентство научных организаций России	0333-2016-0002 (АААА-А16-116121510087-5)
7	Российский научный фонд	19-13-00172

The growing interest in magnetic resonance imaging (MRI) for assessing regional lung function relies on the use of nuclear spin hyperpolarized gas as a contrast agent. The long gas‐phase lifetimes of hyperpolarized 129Xe make this inhalable contrast agent acceptable for clinical research today despite limitations such as high cost, low throughput of production and challenges of 129Xe imaging on clinical MRI scanners, which are normally equipped with proton detection only. We report on low‐cost and high‐throughput preparation of proton‐hyperpolarized diethyl ether, which can be potentially employed for pulmonary imaging with a nontoxic, simple, and sensitive overall strategy using proton detection commonly available on all clinical MRI scanners. Diethyl ether is hyperpolarized by pairwise parahydrogen addition to vinyl ethyl ether and characterized by 1H NMR spectroscopy. Proton polarization levels exceeding 8 % are achieved at near complete chemical conversion within seconds, causing the activation of radio amplification by stimulated emission radiation (RASER) throughout detection. Although gas‐phase T1 relaxation of hyperpolarized diethyl ether (at partial pressure of 0.5 bar) is very efficient, with T1 of ca. 1.2 second, we demonstrate that, at low magnetic fields, the use of long‐lived singlet states created via pairwise parahydrogen addition extends the relaxation decay by approximately threefold, paving the way to bioimaging applications and beyond.

Ariyasingha N.M. , Joalland B. , Younes H.R. , Salnikov O.G. , Chukanov N.V. , Kovtunov K.V. , Kovtunova L.M. , Bukhtiyarov V.I. , Koptyug I.V. , Gelovani J.G. , Chekmenev E.Y.
Parahydrogen‐Induced Polarization of Diethyl Ether Anesthetic

Chemistry - A European Journal. 2020. V.26. N60. P.13621-13626. DOI: 10.1002/chem.202002528, 10.1002/chem.202086063 WOS Scopus РИНЦ РИНЦ CAPlus PMID OpenAlex

Полный текст от издателя

Поступила в редакцию:	23 мая 2020 г.
Принята к публикации:	15 июл. 2020 г.
Опубликована online:	17 сент. 2020 г.
Опубликована в печати:	27 окт. 2020 г.

Web of science:	WOS:000569919800001
Scopus:	2-s2.0-85091153048
РИНЦ:	45277334 \| 76380096
Chemical Abstracts:	2020:1863414
PMID (PubMed):	32667687
OpenAlex:	W3043215589

БД	Цитирований
Scopus	14
Web of science	13
РИНЦ	12
OpenAlex	22