Parahydrogen‐Induced Polarization of Diethyl Ether Anesthetic | Sciact - CRIS-system of Boreskov Institute of Catalysis

Parahydrogen‐Induced Polarization of Diethyl Ether Anesthetic Full article

Journal

Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765

Output data

Year: 2020, Volume: 26, Number: 60, Pages: 13621-13626 Pages count : 7 DOI: 10.1002/chem.202002528, 10.1002/chem.202086063

Tags

anesthetic; hydrogen; hyperpolarization; imaging agents; neurochemistry; parahydrogen

Authors

Ariyasingha Nuwandi M. ¹ , Joalland Baptiste ¹ , Younes Hassan R. ¹ , Salnikov Oleg G. ^2,3,4 , Chukanov Nikita V. ^3,4 , Kovtunov Kirill V. ^3,4 , Kovtunova Larisa M. ^2,3,4 , Bukhtiyarov Valerii I. ^2,4 , Koptyug Igor V. ^3,4 , Gelovani Juri G. ^1,5 , Chekmenev Eduard Y. ^1,6

Affiliations

1	Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202 (USA)
2	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., 630090 Novosibirsk (Russia)
3	International Tomography Center SB RAS, 3A Institutskaya St., 630090 Novosibirsk (Russia)
4	Department of Natural Sciences, Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk (Russia)
5	United Arab Emirates University, Al Ain (United Arab Emirates)
6	Russian Academy of Sciences (RAS),14 Leninskiy Prospekt, 119991 Moscow (Russia)

Funding (7)

1	National Science Foundation	CHE-1904780
2	United States Department of Defense	W81XWH-15-1-0271
3	Russian Foundation for Basic Research	17-54-33037
4	Russian Foundation for Basic Research	19-53-12013 (АААА-А19-119040990042-7)
5	Russian Foundation for Basic Research	19-33-60045
6	Federal Agency for Scientific Organizations	0333-2016-0002 (АААА-А16-116121510087-5)
7	Russian Science Foundation	19-13-00172

The growing interest in magnetic resonance imaging (MRI) for assessing regional lung function relies on the use of nuclear spin hyperpolarized gas as a contrast agent. The long gas‐phase lifetimes of hyperpolarized 129Xe make this inhalable contrast agent acceptable for clinical research today despite limitations such as high cost, low throughput of production and challenges of 129Xe imaging on clinical MRI scanners, which are normally equipped with proton detection only. We report on low‐cost and high‐throughput preparation of proton‐hyperpolarized diethyl ether, which can be potentially employed for pulmonary imaging with a nontoxic, simple, and sensitive overall strategy using proton detection commonly available on all clinical MRI scanners. Diethyl ether is hyperpolarized by pairwise parahydrogen addition to vinyl ethyl ether and characterized by 1H NMR spectroscopy. Proton polarization levels exceeding 8 % are achieved at near complete chemical conversion within seconds, causing the activation of radio amplification by stimulated emission radiation (RASER) throughout detection. Although gas‐phase T1 relaxation of hyperpolarized diethyl ether (at partial pressure of 0.5 bar) is very efficient, with T1 of ca. 1.2 second, we demonstrate that, at low magnetic fields, the use of long‐lived singlet states created via pairwise parahydrogen addition extends the relaxation decay by approximately threefold, paving the way to bioimaging applications and beyond.

Ariyasingha N.M. , Joalland B. , Younes H.R. , Salnikov O.G. , Chukanov N.V. , Kovtunov K.V. , Kovtunova L.M. , Bukhtiyarov V.I. , Koptyug I.V. , Gelovani J.G. , Chekmenev E.Y.
Parahydrogen‐Induced Polarization of Diethyl Ether Anesthetic

Chemistry - A European Journal. 2020. V.26. N60. P.13621-13626. DOI: 10.1002/chem.202002528, 10.1002/chem.202086063 WOS Scopus РИНЦ РИНЦ AN PMID OpenAlex

Full text from publisher

Submitted:	May 23, 2020
Accepted:	Jul 15, 2020
Published online:	Sep 17, 2020
Published print:	Oct 27, 2020

Web of science:	WOS:000569919800001
Scopus:	2-s2.0-85091153048
Elibrary:	45277334 \| 76380096
Chemical Abstracts:	2020:1863414
PMID:	32667687
OpenAlex:	W3043215589

DB	Citing
Scopus	14
Web of science	13
Elibrary	12
OpenAlex	22