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15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields Научная публикация

Журнал Angewandte Chemie - International Edition
ISSN: 1433-7851 , E-ISSN: 1521-3773
Вых. Данные Год: 2021, Том: 60, Номер: 5, Страницы: 2406–2413 Страниц : 8 DOI: 10.1002/anie.202011698
Ключевые слова hyperpolarization; nimorazole; parahydrogen; radiosensitization; SABRE-SHEATH
Авторы Salnikov Oleg G. 1,2,3 , Chukanov Nikita V. 2,3 , Svyatova Alexandra 2,3 , Trofimov Ivan A. 2,3 , Kabir Mohammad S.H. 4 , Gelovani Juri G. 4,5 , Kovtunov Kirill V. 2,3 , Koptyug Igor V. 2,3 , Chekmenev Eduard Y. 4,6
Организации
1 Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., 630090 Novosibirsk (Russia)
2 International Tomography Center SB RAS, 3A Institutskaya St., 630090 Novosibirsk (Russia)
3 Department of Natural Sciences, Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk (Russia)
4 Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, MI 48202 (USA)
5 College of Medicine and Health Sciences, United Arab Emirates University, Al Ain (United Arab Emirates)
6 Russian Academy of Sciences (RAS), 14 Leninskiy Prospekt, 119991 Moscow (Russia)

Информация о финансировании (7)

1 Российский фонд фундаментальных исследований 19-33-60045
2 National Science Foundation CHE-1904780
3 National Institutes of Health 1R21CA220137
4 Российский фонд фундаментальных исследований 17-54-33037
5 Российский фонд фундаментальных исследований 18-33-20019 (АААА-А18-118101090008-1)
6 Российский фонд фундаментальных исследований 19-53-12013 (АААА-А19-119040990042-7)
7 Федеральное агентство научных организаций России 0333-2016-0002 (АААА-А16-116121510087-5)

Реферат: Nimorazole belongs to the imidazole‐based family of antibiotics to fight against anaerobic bacteria. Moreover, nimorazole is now in Phase 3 clinical trial in Europe for potential use as a hypoxia radiosensitizer for treatment of head and neck cancers. We envision the use of [15N3]nimorazole as a theragnostic hypoxia contrast agent that can be potentially deployed in the next‐generation MRI‐LINAC systems. Herein, we report the first steps to create long‐lasting (for tens of minutes) hyperpolarized state on three 15N sites of [15N3]nimorazole with T1 of up to ca. 6 minutes. The nuclear spin polarization was boosted by ca. 67000‐fold at 1.4 T (corresponding to P15N of 3.2 %) by 15N−15N spin‐relayed SABRE‐SHEATH hyperpolarization technique, relying on simultaneous exchange of [15N3]nimorazole and parahydrogen on polarization transfer Ir‐IMes catalyst. The presented results pave the way to efficient spin‐relayed SABRE‐SHEATH hyperpolarization of a wide range of imidazole‐based antibiotics and chemotherapeutics.
Библиографическая ссылка: Salnikov O.G. , Chukanov N.V. , Svyatova A. , Trofimov I.A. , Kabir M.S.H. , Gelovani J.G. , Kovtunov K.V. , Koptyug I.V. , Chekmenev E.Y.
15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields
Angewandte Chemie - International Edition. 2021. V.60. N5. P.2406–2413. DOI: 10.1002/anie.202011698 WOS Scopus РИНЦ CAPlus PMID OpenAlex
Оригинальная: Salnikov O.G. , Chukanov N.V. , Svyatova A. , Trofimov I.A. , Kabir M.S.H. , Gelovani J.G. , Kovtunov K.V. , Koptyug I.V. , Chekmenev E.Y.
15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields
Angewandte Chemie (German edition). 2021. V.133. N5. P.2436–2443. DOI: 10.1002/ange.202011698 РИНЦ OpenAlex
Даты:
Поступила в редакцию: 26 авг. 2020 г.
Опубликована online: 15 окт. 2020 г.
Опубликована в печати: 1 февр. 2021 г.
Идентификаторы БД:
Web of science: WOS:000594405000001
Scopus: 2-s2.0-85097006619
РИНЦ: 45108428
Chemical Abstracts: 2020:2484231
PMID (PubMed): 33063407
OpenAlex: W3092877373
Цитирование в БД:
БД Цитирований
Web of science 34
Scopus 35
РИНЦ 36
OpenAlex 42
Альметрики: