15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields | Sciact - CRIS-система Института катализа

15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields Научная публикация

Журнал

Angewandte Chemie (German edition)
ISSN: 0044-8249 , E-ISSN: 1521-3757

Вых. Данные

Год: 2021, Том: 133, Номер: 5, Страницы: 2436–2443 Страниц : 8 DOI: 10.1002/ange.202011698

Ключевые слова

hyperpolarization; nimorazole; parahydrogen; radiosensitization; SABRE-SHEATH

Авторы

Salnikov Oleg G. ^1,2,3 , Chukanov Nikita V. ^2,3 , Svyatova Alexandra ^2,3 , Trofimov Ivan A. ^2,3 , Kabir Mohammad S.H. ⁴ , Gelovani Juri G. ^4,5 , Kovtunov Kirill V. ^2,3 , Koptyug Igor V. ^2,3 , Chekmenev Eduard Y. ^4,6

Организации

1	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., 630090 Novosibirsk (Russia)
2	International Tomography Center SB RAS, 3A Institutskaya St., 630090 Novosibirsk (Russia)
3	Department of Natural Sciences, Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk (Russia)
4	Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, MI 48202 (USA)
5	College of Medicine and Health Sciences, United Arab Emirates University, Al Ain (United Arab Emirates)
6	Russian Academy of Sciences (RAS), 14 Leninskiy Prospekt, 119991 Moscow (Russia)

Информация о финансировании (7)

1	Российский фонд фундаментальных исследований	19-33-60045
2	National Science Foundation	CHE-1904780
3	National Institutes of Health	1R21CA220137
4	Российский фонд фундаментальных исследований	17-54-33037
5	Российский фонд фундаментальных исследований	18-33-20019 (АААА-А18-118101090008-1)
6	Российский фонд фундаментальных исследований	19-53-12013 (АААА-А19-119040990042-7)
7	Федеральное агентство научных организаций России	0333-2016-0002 (АААА-А16-116121510087-5)

Nimorazole belongs to the imidazole‐based family of antibiotics to fight against anaerobic bacteria. Moreover, nimorazole is now in Phase 3 clinical trial in Europe for potential use as a hypoxia radiosensitizer for treatment of head and neck cancers. We envision the use of [15N3]nimorazole as a theragnostic hypoxia contrast agent that can be potentially deployed in the next‐generation MRI‐LINAC systems. Herein, we report the first steps to create long‐lasting (for tens of minutes) hyperpolarized state on three 15N sites of [15N3]nimorazole with T1 of up to ca. 6 minutes. The nuclear spin polarization was boosted by ca. 67000‐fold at 1.4 T (corresponding to P15N of 3.2 %) by 15N−15N spin‐relayed SABRE‐SHEATH hyperpolarization technique, relying on simultaneous exchange of [15N3]nimorazole and parahydrogen on polarization transfer Ir‐IMes catalyst. The presented results pave the way to efficient spin‐relayed SABRE‐SHEATH hyperpolarization of a wide range of imidazole‐based antibiotics and chemotherapeutics.

Salnikov O.G. , Chukanov N.V. , Svyatova A. , Trofimov I.A. , Kabir M.S.H. , Gelovani J.G. , Kovtunov K.V. , Koptyug I.V. , Chekmenev E.Y.
15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields
Angewandte Chemie (German edition). 2021. V.133. N5. P.2436–2443. DOI: 10.1002/ange.202011698 РИНЦ OpenAlex

Salnikov O.G. , Chukanov N.V. , Svyatova A. , Trofimov I.A. , Kabir M.S.H. , Gelovani J.G. , Kovtunov K.V. , Koptyug I.V. , Chekmenev E.Y.
15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields
Angewandte Chemie - International Edition. 2021. V.60. N5. P.2406–2413. DOI: 10.1002/anie.202011698 WOS Scopus РИНЦ CAPlus PMID OpenAlex

Поступила в редакцию:	26 авг. 2020 г.
Опубликована online:	15 окт. 2020 г.
Опубликована в печати:	1 февр. 2021 г.

РИНЦ:	47501871
OpenAlex:	W4254754975

БД	Цитирований
РИНЦ	2
OpenAlex	8