Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications | Sciact - CRIS-система Института катализа

Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications Научная публикация

Журнал

Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765

Вых. Данные

Год: 2021, Том: 27, Номер: 4, Страницы: 1316-1322 Страниц : 8 DOI: 10.1002/chem.202003638, 10.1002/chem.202180463

Ключевые слова

diethyl ether; hyperpolarization; imaging agents; NMR spectroscopy; parahydrogen-induced polarization

Авторы

Salnikov Oleg G. ^1,2,3 , Svyatova Alexandra ^1,3 , Kovtunova Larisa M. ^1,2,3 , Chukanov Nikita V. ^1,3 , Bukhtiyarov Valerii I. ^2,3 , Kovtunov Kirill V. ^1,3 , Chekmenev Eduard Y. ^4,5 , Koptyug Igor V. ^1,3

Организации

1	International Tomography Center SB RAS, 3A Institutskaya St., 630090 Novosibirsk, Russia
2	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., 630090 Novosibirsk, Russia
3	Department of Natural Sciences, Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk, Russia
4	Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan, 48202 USA
5	Russian Academy of Sciences (RAS), 14 Leninskiy Prospekt, 119991 Moscow, Russia

Информация о финансировании (8)

1	Российский фонд фундаментальных исследований	19-29-10003 (АААА-А19-119100890052-8)
2	Российский фонд фундаментальных исследований	19-33-60045
3	Федеральное агентство научных организаций России	0333-2016-0002 (АААА-А16-116121510087-5)
4	Российский научный фонд	19-13-00047 (АААА-А19-119042990019-3)
5	United States Department of Defense	W81XWH-15-1-0271
6	Российский фонд фундаментальных исследований	19-43-54004
7	United States Department of Defense	W81XWH-20-1-0576
8	National Institutes of Health	1R21HL154032-01

Magnetic resonance imaging (MRI) with the use of hyperpolarized gases as contrast agents provides valuable information on lungs structure and function. While the technology of 129Xe hyperpolarization for clinical MRI research is well developed, it requires the expensive equipment for production and detection of hyperpolarized 129Xe. Herein we present the 1H hyperpolarization of diethyl ether vapor that can be imaged on any clinical MRI scanner. 1H nuclear spin polarization of up to 1.3 % was achieved using heterogeneous hydrogenation of ethyl vinyl ether with parahydrogen over Rh/TiO2 catalyst. Liquefaction of diethyl ether vapor proceeds with partial preservation of hyperpolarization and prolongs its lifetime by ≈10 times. The proof-of-principle 2D 1H MRI of hyperpolarized diethyl ether was demonstrated with 0.1×1.1 mm2 spatial and 120 ms temporal resolution. The long history of use of diethyl ether for anesthesia is expected to facilitate the clinical translation of the presented approach. © 2020 Wiley-VCH GmbH

Salnikov O.G. , Svyatova A. , Kovtunova L.M. , Chukanov N.V. , Bukhtiyarov V.I. , Kovtunov K.V. , Chekmenev E.Y. , Koptyug I.V.
Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications
Chemistry - A European Journal. 2021. V.27. N4. P.1316-1322. DOI: 10.1002/chem.202003638, 10.1002/chem.202180463 WOS Scopus РИНЦ CAPlus PMID OpenAlex

Поступила в редакцию:	5 авг. 2020 г.
Принята к публикации:	29 авг. 2020 г.
Опубликована online:	3 сент. 2020 г.
Опубликована в печати:	18 янв. 2021 г.

Web of science:	WOS:000597240800001
Scopus:	2-s2.0-85097444017
РИНЦ:	45097178
Chemical Abstracts:	2020:2589275
PMID (PubMed):	32881102
OpenAlex:	W3082969557

БД	Цитирований
Scopus	12
Web of science	13
РИНЦ	13
OpenAlex	16