Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications | Sciact - CRIS-system of Boreskov Institute of Catalysis

Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications Full article

Journal

Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765

Output data

Year: 2021, Volume: 27, Number: 4, Pages: 1316-1322 Pages count : 8 DOI: 10.1002/chem.202003638, 10.1002/chem.202180463

Tags

diethyl ether; hyperpolarization; imaging agents; NMR spectroscopy; parahydrogen-induced polarization

Authors

Salnikov Oleg G. ^1,2,3 , Svyatova Alexandra ^1,3 , Kovtunova Larisa M. ^1,2,3 , Chukanov Nikita V. ^1,3 , Bukhtiyarov Valerii I. ^2,3 , Kovtunov Kirill V. ^1,3 , Chekmenev Eduard Y. ^4,5 , Koptyug Igor V. ^1,3

Affiliations

1	International Tomography Center SB RAS, 3A Institutskaya St., 630090 Novosibirsk, Russia
2	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., 630090 Novosibirsk, Russia
3	Department of Natural Sciences, Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk, Russia
4	Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan, 48202 USA
5	Russian Academy of Sciences (RAS), 14 Leninskiy Prospekt, 119991 Moscow, Russia

Funding (8)

1	Russian Foundation for Basic Research	19-29-10003 (АААА-А19-119100890052-8)
2	Russian Foundation for Basic Research	19-33-60045
3	Federal Agency for Scientific Organizations	0333-2016-0002 (АААА-А16-116121510087-5)
4	Russian Science Foundation	19-13-00047 (АААА-А19-119042990019-3)
5	United States Department of Defense	W81XWH-15-1-0271
6	Russian Foundation for Basic Research	19-43-54004
7	United States Department of Defense	W81XWH-20-1-0576
8	National Institutes of Health	1R21HL154032-01

Magnetic resonance imaging (MRI) with the use of hyperpolarized gases as contrast agents provides valuable information on lungs structure and function. While the technology of 129Xe hyperpolarization for clinical MRI research is well developed, it requires the expensive equipment for production and detection of hyperpolarized 129Xe. Herein we present the 1H hyperpolarization of diethyl ether vapor that can be imaged on any clinical MRI scanner. 1H nuclear spin polarization of up to 1.3 % was achieved using heterogeneous hydrogenation of ethyl vinyl ether with parahydrogen over Rh/TiO2 catalyst. Liquefaction of diethyl ether vapor proceeds with partial preservation of hyperpolarization and prolongs its lifetime by ≈10 times. The proof-of-principle 2D 1H MRI of hyperpolarized diethyl ether was demonstrated with 0.1×1.1 mm2 spatial and 120 ms temporal resolution. The long history of use of diethyl ether for anesthesia is expected to facilitate the clinical translation of the presented approach. © 2020 Wiley-VCH GmbH

Salnikov O.G. , Svyatova A. , Kovtunova L.M. , Chukanov N.V. , Bukhtiyarov V.I. , Kovtunov K.V. , Chekmenev E.Y. , Koptyug I.V.
Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications
Chemistry - A European Journal. 2021. V.27. N4. P.1316-1322. DOI: 10.1002/chem.202003638, 10.1002/chem.202180463 WOS Scopus РИНЦ AN PMID OpenAlex

Submitted:	Aug 5, 2020
Accepted:	Aug 29, 2020
Published online:	Sep 3, 2020
Published print:	Jan 18, 2021

Web of science:	WOS:000597240800001
Scopus:	2-s2.0-85097444017
Elibrary:	45097178
Chemical Abstracts:	2020:2589275
PMID:	32881102
OpenAlex:	W3082969557

DB	Citing
Scopus	12
Web of science	12
Elibrary	13
OpenAlex	15