Titanium Salan Catalysts for the Asymmetric Epoxidation of Alkenes: Steric and Electronic Factors Governing the Activity and Enantioselectivity Научная публикация
| Журнал |
Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765 |
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| Вых. Данные | Год: 2014, Том: 20, Номер: 44, Страницы: 14329-14335 Страниц : 7 DOI: 10.1002/chem.201404157, 10.1002/chin.201515136 | ||||||
| Ключевые слова | Asymmetric catalysis, Epoxidation, Green chemistry, Peroxides, Reaction mechanisms | ||||||
| Авторы |
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| Организации |
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Информация о финансировании (1)
| 1 | Российский научный фонд | 14-13-00158 |
Реферат:
A new insight into the highly enantioselective (up to >99.5 % ee) epoxidation of olefins in the presence of chiral titanium(IV) salan complexes is reported. A series of 14 chiral ligands with varying steric and electronic properties have been designed, and it was found that electronic effects modulate the catalytic activity (without affecting the enantioselectivity), whereas the steric properties account for the enantioselectivity of the epoxidation. Competitive oxidations of p-substituted styrenes reveal the electrophilic nature of the oxygen-transferring active species, with a Hammett ρ value of −0.51; the enantioselectivity is unaffected by the electron-donating (or withdrawing) ability of the p-substituents. Mechanistic studies provide evidence in favor of a stepwise reaction mechanism: in the first (rate-determining) stage, olefin most probably coordinates to the active species, followed by intramolecular enantioselective oxygen transfer. The enantioselectivity increases with decreasing temperature. The modified Eyring plots for the epoxidation of styrene and (Z)-β-methylstyrene are linear, indicating a single, enthalpy-controlled mechanism of stereoselectivity, with ΔΔH≠=−6.6 kJ mol−1 and −5.4 kJ mol−1, respectively.
Библиографическая ссылка:
Talsi E.P.
, Samsonenko D.G.
, Bryliakov K.P.
Titanium Salan Catalysts for the Asymmetric Epoxidation of Alkenes: Steric and Electronic Factors Governing the Activity and Enantioselectivity
Chemistry - A European Journal. 2014. V.20. N44. P.14329-14335. DOI: 10.1002/chem.201404157, 10.1002/chin.201515136 WOS Scopus РИНЦ CAPlusCA PMID OpenAlex
Titanium Salan Catalysts for the Asymmetric Epoxidation of Alkenes: Steric and Electronic Factors Governing the Activity and Enantioselectivity
Chemistry - A European Journal. 2014. V.20. N44. P.14329-14335. DOI: 10.1002/chem.201404157, 10.1002/chin.201515136 WOS Scopus РИНЦ CAPlusCA PMID OpenAlex
Даты:
| Поступила в редакцию: | 28 июн. 2014 г. |
| Опубликована online: | 11 сент. 2014 г. |
| Опубликована в печати: | 27 окт. 2014 г. |
Идентификаторы БД:
| Web of science: | WOS:000344224800024 |
| Scopus: | 2-s2.0-84915783795 |
| РИНЦ: | 24013172 |
| Chemical Abstracts: | 2014:1525977 |
| Chemical Abstracts (print): | 162:36923 |
| PMID (PubMed): | 25213492 |
| OpenAlex: | W2146765647 |