Titanium Salan Catalysts for the Asymmetric Epoxidation of Alkenes: Steric and Electronic Factors Governing the Activity and Enantioselectivity Full article
| Journal |
Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765 |
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| Output data | Year: 2014, Volume: 20, Number: 44, Pages: 14329-14335 Pages count : 7 DOI: 10.1002/chem.201404157, 10.1002/chin.201515136 | ||||||
| Tags | Asymmetric catalysis, Epoxidation, Green chemistry, Peroxides, Reaction mechanisms | ||||||
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| Affiliations |
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Funding (1)
| 1 | Russian Science Foundation | 14-13-00158 |
Abstract:
A new insight into the highly enantioselective (up to >99.5 % ee) epoxidation of olefins in the presence of chiral titanium(IV) salan complexes is reported. A series of 14 chiral ligands with varying steric and electronic properties have been designed, and it was found that electronic effects modulate the catalytic activity (without affecting the enantioselectivity), whereas the steric properties account for the enantioselectivity of the epoxidation. Competitive oxidations of p-substituted styrenes reveal the electrophilic nature of the oxygen-transferring active species, with a Hammett ρ value of −0.51; the enantioselectivity is unaffected by the electron-donating (or withdrawing) ability of the p-substituents. Mechanistic studies provide evidence in favor of a stepwise reaction mechanism: in the first (rate-determining) stage, olefin most probably coordinates to the active species, followed by intramolecular enantioselective oxygen transfer. The enantioselectivity increases with decreasing temperature. The modified Eyring plots for the epoxidation of styrene and (Z)-β-methylstyrene are linear, indicating a single, enthalpy-controlled mechanism of stereoselectivity, with ΔΔH≠=−6.6 kJ mol−1 and −5.4 kJ mol−1, respectively.
Cite:
Talsi E.P.
, Samsonenko D.G.
, Bryliakov K.P.
Titanium Salan Catalysts for the Asymmetric Epoxidation of Alkenes: Steric and Electronic Factors Governing the Activity and Enantioselectivity
Chemistry - A European Journal. 2014. V.20. N44. P.14329-14335. DOI: 10.1002/chem.201404157, 10.1002/chin.201515136 WOS Scopus РИНЦ ANCAN PMID OpenAlex
Titanium Salan Catalysts for the Asymmetric Epoxidation of Alkenes: Steric and Electronic Factors Governing the Activity and Enantioselectivity
Chemistry - A European Journal. 2014. V.20. N44. P.14329-14335. DOI: 10.1002/chem.201404157, 10.1002/chin.201515136 WOS Scopus РИНЦ ANCAN PMID OpenAlex
Dates:
| Submitted: | Jun 28, 2014 |
| Published online: | Sep 11, 2014 |
| Published print: | Oct 27, 2014 |
Identifiers:
| Web of science: | WOS:000344224800024 |
| Scopus: | 2-s2.0-84915783795 |
| Elibrary: | 24013172 |
| Chemical Abstracts: | 2014:1525977 |
| Chemical Abstracts (print): | 162:36923 |
| PMID: | 25213492 |
| OpenAlex: | W2146765647 |