Strategy of an in vivo Study of the Evolution of Drugs via X-Ray Diffraction with Synchrotron Radiation | Sciact - CRIS-система Института катализа

Strategy of an in vivo Study of the Evolution of Drugs via X-Ray Diffraction with Synchrotron Radiation Научная публикация

Журнал

Bulletin of the Russian Academy of Sciences: Physics
ISSN: 1062-8738 , E-ISSN: 1934-9432

Вых. Данные

Год: 2018, Том: 82, Номер: 7, Страницы: 895-897 Страниц : 3 DOI: 10.3103/s1062873818070353

Ключевые слова

Biology; Bismuth; Synchrotron radiation; Synchrotrons; X ray diffraction

Авторы

Sharafutdinov M.R. ^1,2 , Tolochko B.P. ^1,2 , Kuper K.E. ² , Ancharov A.I. ^1,2

Организации

1	Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences
2	Budker Institute of Nuclear Physics, Siberian Branch, Russian Academy of Sciences

A new approach to the diagnostics of the evolution of drugs in a living organism by means of synchrotron X-ray radiation diffractometry is proposed. A drug is first localized via differential radiography, and a microbeam is then used to obtain the X-ray diffraction patterns of the corresponding area. Bismuth tripotassium dicytrate (BTD) is used as a test material. It is both introduced inside a stomach of a mouse and used in experiments with a phantom. It is shown experimentally and theoretically that an energy of 90.5 keV near the K-edge of bismuth is most effective in this approach. The possibility applying it to the diagnostics of a human body is demonstrated.

Sharafutdinov M.R. , Tolochko B.P. , Kuper K.E. , Ancharov A.I.
Strategy of an in vivo Study of the Evolution of Drugs via X-Ray Diffraction with Synchrotron Radiation
Bulletin of the Russian Academy of Sciences: Physics. 2018. V.82. N7. P.895-897. DOI: 10.3103/s1062873818070353 Scopus CAPlusCA OpenAlex

Шарафутдинов М.Р. , Толочко Б.П. , Купер К.Э. , Анчаров А.И.
Стратегия in vivo-исследования поведения лекарственных форм рентген-дифракционными методами на пучках синхротронного излучения
Известия Российской академии наук. Серия физическая. 2018. Т.82. №7. С.986-988. DOI: 10.1134/S0367676518070359 РИНЦ OpenAlex

Опубликована в печати:	1 июл. 2018 г.
Опубликована online:	3 авг. 2018 г.

Scopus:	2-s2.0-85051066111
Chemical Abstracts:	2018:1446019
Chemical Abstracts (print):	174:413660 CAplus
OpenAlex:	W2887446925

Пока нет цитирований