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Strategy of an in vivo Study of the Evolution of Drugs via X-Ray Diffraction with Synchrotron Radiation Full article

Journal Bulletin of the Russian Academy of Sciences: Physics
ISSN: 1062-8738 , E-ISSN: 1934-9432
Output data Year: 2018, Volume: 82, Number: 7, Pages: 895-897 Pages count : 3 DOI: 10.3103/s1062873818070353
Tags Biology; Bismuth; Synchrotron radiation; Synchrotrons; X ray diffraction
Authors Sharafutdinov M.R. 1,2 , Tolochko B.P. 1,2 , Kuper K.E. 2 , Ancharov A.I. 1,2
Affiliations
1 Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences
2 Budker Institute of Nuclear Physics, Siberian Branch, Russian Academy of Sciences

Abstract: A new approach to the diagnostics of the evolution of drugs in a living organism by means of synchrotron X-ray radiation diffractometry is proposed. A drug is first localized via differential radiography, and a microbeam is then used to obtain the X-ray diffraction patterns of the corresponding area. Bismuth tripotassium dicytrate (BTD) is used as a test material. It is both introduced inside a stomach of a mouse and used in experiments with a phantom. It is shown experimentally and theoretically that an energy of 90.5 keV near the K-edge of bismuth is most effective in this approach. The possibility applying it to the diagnostics of a human body is demonstrated.
Cite: Sharafutdinov M.R. , Tolochko B.P. , Kuper K.E. , Ancharov A.I.
Strategy of an in vivo Study of the Evolution of Drugs via X-Ray Diffraction with Synchrotron Radiation
Bulletin of the Russian Academy of Sciences: Physics. 2018. V.82. N7. P.895-897. DOI: 10.3103/s1062873818070353 Scopus ANCAN OpenAlex
Original: Шарафутдинов М.Р. , Толочко Б.П. , Купер К.Э. , Анчаров А.И.
Стратегия in vivo-исследования поведения лекарственных форм рентген-дифракционными методами на пучках синхротронного излучения
Известия Российской академии наук. Серия физическая. 2018. Т.82. №7. С.986-988. DOI: 10.1134/S0367676518070359 РИНЦ OpenAlex
Dates:
Published print: Jul 1, 2018
Published online: Aug 3, 2018
Identifiers:
Scopus: 2-s2.0-85051066111
Chemical Abstracts: 2018:1446019
Chemical Abstracts (print): 174:413660 CAplus
OpenAlex: W2887446925
Citing: Пока нет цитирований
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