Strategy of an in vivo Study of the Evolution of Drugs via X-Ray Diffraction with Synchrotron Radiation | Sciact - CRIS-system of Boreskov Institute of Catalysis

Strategy of an in vivo Study of the Evolution of Drugs via X-Ray Diffraction with Synchrotron Radiation Full article

Journal

Bulletin of the Russian Academy of Sciences: Physics
ISSN: 1062-8738 , E-ISSN: 1934-9432

Output data

Year: 2018, Volume: 82, Number: 7, Pages: 895-897 Pages count : 3 DOI: 10.3103/s1062873818070353

Tags

Biology; Bismuth; Synchrotron radiation; Synchrotrons; X ray diffraction

Authors

Sharafutdinov M.R. ^1,2 , Tolochko B.P. ^1,2 , Kuper K.E. ² , Ancharov A.I. ^1,2

Affiliations

1	Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences
2	Budker Institute of Nuclear Physics, Siberian Branch, Russian Academy of Sciences

A new approach to the diagnostics of the evolution of drugs in a living organism by means of synchrotron X-ray radiation diffractometry is proposed. A drug is first localized via differential radiography, and a microbeam is then used to obtain the X-ray diffraction patterns of the corresponding area. Bismuth tripotassium dicytrate (BTD) is used as a test material. It is both introduced inside a stomach of a mouse and used in experiments with a phantom. It is shown experimentally and theoretically that an energy of 90.5 keV near the K-edge of bismuth is most effective in this approach. The possibility applying it to the diagnostics of a human body is demonstrated.

Sharafutdinov M.R. , Tolochko B.P. , Kuper K.E. , Ancharov A.I.
Strategy of an in vivo Study of the Evolution of Drugs via X-Ray Diffraction with Synchrotron Radiation
Bulletin of the Russian Academy of Sciences: Physics. 2018. V.82. N7. P.895-897. DOI: 10.3103/s1062873818070353 Scopus ANCAN OpenAlex

Шарафутдинов М.Р. , Толочко Б.П. , Купер К.Э. , Анчаров А.И.
Стратегия in vivo-исследования поведения лекарственных форм рентген-дифракционными методами на пучках синхротронного излучения
Известия Российской академии наук. Серия физическая. 2018. Т.82. №7. С.986-988. DOI: 10.1134/S0367676518070359 РИНЦ OpenAlex

Published print:	Jul 1, 2018
Published online:	Aug 3, 2018

Scopus:	2-s2.0-85051066111
Chemical Abstracts:	2018:1446019
Chemical Abstracts (print):	174:413660 CAplus
OpenAlex:	W2887446925

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