Diffusion of Lipid Nanovesicles Bound to a Lipid Membrane Is Associated with the Partial-Slip Boundary Condition | Sciact - CRIS-система Института катализа

Diffusion of Lipid Nanovesicles Bound to a Lipid Membrane Is Associated with the Partial-Slip Boundary Condition Научная публикация

Журнал

Nano Letters
ISSN: 1530-6984 , E-ISSN: 1530-6992

Вых. Данные

Год: 2021, Том: 21, Номер: 19, Страницы: 8503–8509 Страниц : 7 DOI: 10.1021/acs.nanolett.1c02092

Ключевые слова

Multivalent interactions; single-particle tracking; lipid vesicles; confined diffusion; slip length

Авторы

Olsén Erik ¹ , Jõemetsa Silver ¹ , González Adrián ¹ , Joyce Paul ^1,2 , Zhdanov Vladimir P. ^1,3 , Midtvedt Daniel ¹ , Höök Fredrik ¹

Организации

1	Department of Physics, Chalmers University of Technology, SE-41296 Göteborg, Sweden
2	UniSA: Clinical and Health Sciences, University of South Australia, 5000 Adelaide, Australia
3	Boreskov Institute of Catalysis, Russian Academy of Sciences, Novosibirsk 630090, Russia

Информация о финансировании (4)

1	Фонд Кнута и Элис Валленберг	2019-0577
2	Swedish Research Council	2018-3309
3	Swedish Research Council	2019-05071
4	Chalmers University of Technology

During diffusion of nanoparticles bound to a cellular membrane by ligand–receptor pairs, the distance to the laterally mobile interface is sufficiently short for their motion to depend not only on the membrane-mediated diffusivity of the tethers but also in a not yet fully understood manner on nanoparticle size and interfacial hydrodynamics. By quantifying diffusivity, velocity, and size of individual membrane-bound liposomes subjected to a hydrodynamic shear flow, we have successfully separated the diffusivity contributions from particle size and number of tethers. The obtained diffusion-size relations for synthetic and extracellular lipid vesicles are not well-described by the conventional no-slip boundary condition, suggesting partial slip as well as a significant diffusivity dependence on the distance to the lipid bilayer. These insights, extending the understanding of diffusion of biological nanoparticles at lipid bilayers, are of relevance for processes such as cellular uptake of viruses and lipid nanoparticles or labeling of cell-membrane-residing molecules.

Olsén E. , Jõemetsa S. , González A. , Joyce P. , Zhdanov V.P. , Midtvedt D. , Höök F.
Diffusion of Lipid Nanovesicles Bound to a Lipid Membrane Is Associated with the Partial-Slip Boundary Condition
Nano Letters. 2021. V.21. N19. P.8503–8509. DOI: 10.1021/acs.nanolett.1c02092 WOS Scopus РИНЦ CAPlus PMID OpenAlex

Поступила в редакцию:	27 мая 2021 г.
Принята к публикации:	6 авг. 2021 г.
Опубликована online:	17 авг. 2021 г.
Опубликована в печати:	13 окт. 2021 г.

Web of science:	WOS:000709549100078
Scopus:	2-s2.0-85114383034
РИНЦ:	47098364
Chemical Abstracts:	2021:1793301
PMID (PubMed):	34403260
OpenAlex:	W3196247820

БД	Цитирований
Scopus	5
Web of science	5
РИНЦ	4
OpenAlex	5