Diffusion of Lipid Nanovesicles Bound to a Lipid Membrane Is Associated with the Partial-Slip Boundary Condition Full article
| Journal |
Nano Letters
ISSN: 1530-6984 , E-ISSN: 1530-6992 |
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| Output data | Year: 2021, Volume: 21, Number: 19, Pages: 8503–8509 Pages count : 7 DOI: 10.1021/acs.nanolett.1c02092 | ||||||
| Tags | Multivalent interactions; single-particle tracking; lipid vesicles; confined diffusion; slip length | ||||||
| Authors |
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| Affiliations |
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Funding (4)
| 1 | Knut and Alice Wallenberg Foundation | 2019-0577 |
| 2 | Swedish Research Council | 2018-3309 |
| 3 | Swedish Research Council | 2019-05071 |
| 4 | Chalmers University of Technology |
Abstract:
During diffusion of nanoparticles bound to a cellular membrane by ligand–receptor pairs, the distance to the laterally mobile interface is sufficiently short for their motion to depend not only on the membrane-mediated diffusivity of the tethers but also in a not yet fully understood manner on nanoparticle size and interfacial hydrodynamics. By quantifying diffusivity, velocity, and size of individual membrane-bound liposomes subjected to a hydrodynamic shear flow, we have successfully separated the diffusivity contributions from particle size and number of tethers. The obtained diffusion-size relations for synthetic and extracellular lipid vesicles are not well-described by the conventional no-slip boundary condition, suggesting partial slip as well as a significant diffusivity dependence on the distance to the lipid bilayer. These insights, extending the understanding of diffusion of biological nanoparticles at lipid bilayers, are of relevance for processes such as cellular uptake of viruses and lipid nanoparticles or labeling of cell-membrane-residing molecules.
Cite:
Olsén E.
, Jõemetsa S.
, González A.
, Joyce P.
, Zhdanov V.P.
, Midtvedt D.
, Höök F.
Diffusion of Lipid Nanovesicles Bound to a Lipid Membrane Is Associated with the Partial-Slip Boundary Condition
Nano Letters. 2021. V.21. N19. P.8503–8509. DOI: 10.1021/acs.nanolett.1c02092 WOS Scopus РИНЦ AN PMID OpenAlex
Diffusion of Lipid Nanovesicles Bound to a Lipid Membrane Is Associated with the Partial-Slip Boundary Condition
Nano Letters. 2021. V.21. N19. P.8503–8509. DOI: 10.1021/acs.nanolett.1c02092 WOS Scopus РИНЦ AN PMID OpenAlex
Dates:
| Submitted: | May 27, 2021 |
| Accepted: | Aug 6, 2021 |
| Published online: | Aug 17, 2021 |
| Published print: | Oct 13, 2021 |
Identifiers:
| Web of science: | WOS:000709549100078 |
| Scopus: | 2-s2.0-85114383034 |
| Elibrary: | 47098364 |
| Chemical Abstracts: | 2021:1793301 |
| PMID: | 34403260 |
| OpenAlex: | W3196247820 |