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Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs): Nanostructure of the Glassy State Studied by Electron Paramagnetic Resonance Spectroscopy Научная публикация

Журнал Molecules
ISSN: 1420-3049
Вых. Данные Год: 2022, Том: 27, Номер: 16, Номер статьи : 5117, Страниц : 11 DOI: 10.3390/molecules27165117
Ключевые слова EPR; ionic liquids; pharmaceuticals; nanostructuring; spin probes
Авторы Bakulina Olga D. 1,2 , Ivanov Mikhail Yu. 1,2 , Alimov Dmitriy V. 1,2 , Prikhod’ko Sergey A. 3 , Adonin Nicolay Yu. 3 , Fedin Matvey V. 1,2
Организации
1 International Tomography Center SB RAS, Institutskaya Street 3a, 630090 Novosibirsk, Russia
2 Physics Department, Novosibirsk State University, Pirogova Street 2, 630090 Novosibirsk, Russia
3 Boreskov Institute of Catalysis SB RAS, Lavrentiev Avenue 5, 630090 Novosibirsk, Russia

Информация о финансировании (1)

1 Российский научный фонд 19-13-00071

Реферат: Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs) draw increasing interest as a particular class of ILs that possess unusual physicochemical properties along with simultaneous potentials for pharmaceutical applications. Although nanostructuring phenomena were actively investigated in common ILs, their studies in API-ILs are scarce so far. In this work, using the complex methodology of Electron Paramagnetic Resonance (EPR) and dissolved spin probes, we investigate nanostructuring phenomena in a series of API-ILs: [Cnmim][Ibu], [Cnmim][Gly], and [Cnmim][Sal] with n = 2, 4, and 6, respectively. We reveal similar trends for API-ILs and common ILs, as well as peculiarities inherent to the studied API-ILs. Unusual behavior observed for [Cnmim][Ibu] has been assigned to the presence of a non-polar fragment in the [Ibu]− anion, which leads to the formation of more complex nanostructures around the radical compared to common ILs. Understanding general trends in the formation of such self-organized molecular structures is of fundamental interest and importance for applying API-ILs.
Библиографическая ссылка: Bakulina O.D. , Ivanov M.Y. , Alimov D.V. , Prikhod’ko S.A. , Adonin N.Y. , Fedin M.V.
Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs): Nanostructure of the Glassy State Studied by Electron Paramagnetic Resonance Spectroscopy
Molecules. 2022. V.27. N16. 5117 :1-11. DOI: 10.3390/molecules27165117 WOS Scopus РИНЦ CAPlusCA PMID OpenAlex
Даты:
Поступила в редакцию: 11 июл. 2022 г.
Принята к публикации: 2 авг. 2022 г.
Опубликована в печати: 11 авг. 2022 г.
Опубликована online: 11 авг. 2022 г.
Идентификаторы БД:
Web of science: WOS:000845337000001
Scopus: 2-s2.0-85136694153
РИНЦ: 50361632
Chemical Abstracts: 2022:2287844
Chemical Abstracts (print): 180:149422
PMID (PubMed): 36014356
OpenAlex: W4290998939
Цитирование в БД:
БД Цитирований
Scopus 8
Web of science 7
РИНЦ 7
OpenAlex 8
Альметрики: