Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs): Nanostructure of the Glassy State Studied by Electron Paramagnetic Resonance Spectroscopy | Sciact - CRIS-система Института катализа

Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs): Nanostructure of the Glassy State Studied by Electron Paramagnetic Resonance Spectroscopy Научная публикация

Журнал

Molecules
ISSN: 1420-3049

Вых. Данные

Год: 2022, Том: 27, Номер: 16, Номер статьи : 5117, Страниц : 11 DOI: 10.3390/molecules27165117

Ключевые слова

EPR; ionic liquids; pharmaceuticals; nanostructuring; spin probes

Авторы

Bakulina Olga D. ^1,2 , Ivanov Mikhail Yu. ^1,2 , Alimov Dmitriy V. ^1,2 , Prikhod’ko Sergey A. ³ , Adonin Nicolay Yu. ³ , Fedin Matvey V. ^1,2

Организации

1	International Tomography Center SB RAS, Institutskaya Street 3a, 630090 Novosibirsk, Russia
2	Physics Department, Novosibirsk State University, Pirogova Street 2, 630090 Novosibirsk, Russia
3	Boreskov Institute of Catalysis SB RAS, Lavrentiev Avenue 5, 630090 Novosibirsk, Russia

Информация о финансировании (1)

Российский научный фонд

19-13-00071

Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs) draw increasing interest as a particular class of ILs that possess unusual physicochemical properties along with simultaneous potentials for pharmaceutical applications. Although nanostructuring phenomena were actively investigated in common ILs, their studies in API-ILs are scarce so far. In this work, using the complex methodology of Electron Paramagnetic Resonance (EPR) and dissolved spin probes, we investigate nanostructuring phenomena in a series of API-ILs: [Cnmim][Ibu], [Cnmim][Gly], and [Cnmim][Sal] with n = 2, 4, and 6, respectively. We reveal similar trends for API-ILs and common ILs, as well as peculiarities inherent to the studied API-ILs. Unusual behavior observed for [Cnmim][Ibu] has been assigned to the presence of a non-polar fragment in the [Ibu]− anion, which leads to the formation of more complex nanostructures around the radical compared to common ILs. Understanding general trends in the formation of such self-organized molecular structures is of fundamental interest and importance for applying API-ILs.

Bakulina O.D. , Ivanov M.Y. , Alimov D.V. , Prikhod’ko S.A. , Adonin N.Y. , Fedin M.V.
Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs): Nanostructure of the Glassy State Studied by Electron Paramagnetic Resonance Spectroscopy
Molecules. 2022. V.27. N16. 5117 :1-11. DOI: 10.3390/molecules27165117 WOS Scopus РИНЦ CAPlusCA PMID OpenAlex

Поступила в редакцию:	11 июл. 2022 г.
Принята к публикации:	2 авг. 2022 г.
Опубликована в печати:	11 авг. 2022 г.
Опубликована online:	11 авг. 2022 г.

Web of science:	WOS:000845337000001
Scopus:	2-s2.0-85136694153
РИНЦ:	50361632
Chemical Abstracts:	2022:2287844
Chemical Abstracts (print):	180:149422
PMID (PubMed):	36014356
OpenAlex:	W4290998939

БД	Цитирований
Scopus	5
Web of science	5
РИНЦ	6
OpenAlex	5