Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs): Nanostructure of the Glassy State Studied by Electron Paramagnetic Resonance Spectroscopy Full article
| Journal |
Molecules
ISSN: 1420-3049 |
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| Output data | Year: 2022, Volume: 27, Number: 16, Article number : 5117, Pages count : 11 DOI: 10.3390/molecules27165117 | ||||||
| Tags | EPR; ionic liquids; pharmaceuticals; nanostructuring; spin probes | ||||||
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| Affiliations |
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Funding (1)
| 1 | Russian Science Foundation | 19-13-00071 |
Abstract:
Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs) draw increasing interest as a particular class of ILs that possess unusual physicochemical properties along with simultaneous potentials for pharmaceutical applications. Although nanostructuring phenomena were actively investigated in common ILs, their studies in API-ILs are scarce so far. In this work, using the complex methodology of Electron Paramagnetic Resonance (EPR) and dissolved spin probes, we investigate nanostructuring phenomena in a series of API-ILs: [Cnmim][Ibu], [Cnmim][Gly], and [Cnmim][Sal] with n = 2, 4, and 6, respectively. We reveal similar trends for API-ILs and common ILs, as well as peculiarities inherent to the studied API-ILs. Unusual behavior observed for [Cnmim][Ibu] has been assigned to the presence of a non-polar fragment in the [Ibu]− anion, which leads to the formation of more complex nanostructures around the radical compared to common ILs. Understanding general trends in the formation of such self-organized molecular structures is of fundamental interest and importance for applying API-ILs.
Cite:
Bakulina O.D.
, Ivanov M.Y.
, Alimov D.V.
, Prikhod’ko S.A.
, Adonin N.Y.
, Fedin M.V.
Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs): Nanostructure of the Glassy State Studied by Electron Paramagnetic Resonance Spectroscopy
Molecules. 2022. V.27. N16. 5117 :1-11. DOI: 10.3390/molecules27165117 WOS Scopus РИНЦ ANCAN PMID OpenAlex
Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs): Nanostructure of the Glassy State Studied by Electron Paramagnetic Resonance Spectroscopy
Molecules. 2022. V.27. N16. 5117 :1-11. DOI: 10.3390/molecules27165117 WOS Scopus РИНЦ ANCAN PMID OpenAlex
Dates:
| Submitted: | Jul 11, 2022 |
| Accepted: | Aug 2, 2022 |
| Published print: | Aug 11, 2022 |
| Published online: | Aug 11, 2022 |
Identifiers:
| Web of science: | WOS:000845337000001 |
| Scopus: | 2-s2.0-85136694153 |
| Elibrary: | 50361632 |
| Chemical Abstracts: | 2022:2287844 |
| Chemical Abstracts (print): | 180:149422 |
| PMID: | 36014356 |
| OpenAlex: | W4290998939 |