Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation | Sciact - CRIS-система Института катализа

Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation Научная публикация

Журнал

Analytical Chemistry
ISSN: 0003-2700 , E-ISSN: 1520-6882

Вых. Данные

Год: 2022, Том: 94, Номер: 43, Страницы: 15010-15017 Страниц : 8 DOI: 10.1021/acs.analchem.2c02929

Ключевые слова

through space multinuclear magnetic resonance signal enhancement parahydrogen; radio frequency amplification stimulated emission radiation; hyperpolarized nuclear spin

Авторы

Salnikov Oleg G. ^1,2 , Trofimov Ivan A. ^1,3 , Pravdivtsev Andrey N. ⁴ , Them Kolja ⁴ , Hövener Jan-Bernd ⁴ , Chekmenev Eduard Y. ^5,6 , Koptyug Igor V. ¹

Организации

1	International Tomography Center SB RAS, 3A Institutskaya St., 630090 Novosibirsk, Russia
2	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., 630090 Novosibirsk, Russia
3	Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk, Russia
4	Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein and Kiel University, 24118 Kiel, Germany
5	Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202, United States
6	Russian Academy of Sciences, 14 Leninskiy Pr., 119991 Moscow, Russia

Информация о финансировании (19)

1	Российский фонд фундаментальных исследований	19-33-60045
2	Совет по грантам Президента Российской Федерации	МК-2826.2022.1.3
3	Российский научный фонд	21-73-10105 (121121600301-4)
4	Federal Ministry of Education and Research	01ZX1915C
5	United States Department of Defense	W81XWH-20-10576
6	National Institute of Biomedical Imaging and Bioengineering	1R01EB029829
7	National Institutes of Health	1R21HL154032-01
8	German Research Foundation	GRK 2154/1-2019
9	European Commission	122-09-053
10	National Science Foundation	CHE-1904780
11	National Institutes of Health	1R21CA220137
12	German Research Foundation	HO 4602/3
13	German Research Foundation	HO 4602/2-2
14	German Research Foundation	PR1868/3-1
15	German Research Foundation	EXC2167
16	German Research Foundation	FOR5042
17	German Research Foundation	TRR287
18	German Research Foundation	SFB 1479
19	Министерство науки и высшего образования Российской Федерации (с 15 мая 2018)

Hyperpolarized (i.e., polarized far beyond the thermal equilibrium) nuclear spins can result in the radiofrequency amplification by stimulated emission of radiation (RASER) effect. Here, we show the utility of RASER to amplify nuclear magnetic resonance (NMR) signals of solute and solvent molecules in the liquid state. Specifically, parahydrogen-induced RASER was used to spontaneously enhance nuclear spin polarization of protons and heteronuclei (here 19F and 31P) in a wide range of molecules. The magnitude of the effect correlates with the T1 relaxation time of the target nuclear spins. A series of control experiments validate the through-space dipolar mechanism of the RASER-assisted polarization transfer between the parahydrogen-polarized compound and to-be-hyperpolarized nuclei of the target molecule. Frequency-selective saturation of the RASER-active resonances was used to control the RASER and the amplitude of spontaneous polarization transfer. Spin dynamics simulations support our experimental RASER studies. The enhanced NMR sensitivity may benefit various NMR applications such as mixture analysis, metabolomics, and structure determination.

Salnikov O.G. , Trofimov I.A. , Pravdivtsev A.N. , Them K. , Hövener J-B. , Chekmenev E.Y. , Koptyug I.V.
Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation
Analytical Chemistry. 2022. V.94. N43. P.15010-15017. DOI: 10.1021/acs.analchem.2c02929 WOS Scopus РИНЦ OpenAlex CAPlus PMID DOI (дополнительный)

Поступила в редакцию:	7 июл. 2022 г.
Принята к публикации:	7 окт. 2022 г.
Опубликована online:	20 окт. 2022 г.
Опубликована в печати:	1 нояб. 2022 г.

≡ Web of science:	WOS:000888011300001
≡ Scopus:	2-s2.0-85141743110
≡ РИНЦ:	54731934
≡ OpenAlex:	W4306893554
≡ Chemical Abstracts:	2022:2663707
≡ PMID (PubMed):	36264746
≡ DOI (дополнительный):	10.26434/chemrxiv-2022-dp639

≡ Scopus	18	Сбор данных от 15.02.2026
≡ Web of science	17	Сбор данных от 13.02.2026
≡ OpenAlex	21	Сбор данных от 15.02.2026
≡ РИНЦ	17	Сбор данных от 15.02.2026