Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation | Sciact - CRIS-system of Boreskov Institute of Catalysis

Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation Full article

Journal

Analytical Chemistry
ISSN: 0003-2700 , E-ISSN: 1520-6882

Output data

Year: 2022, Volume: 94, Number: 43, Pages: 15010-15017 Pages count : 8 DOI: 10.1021/acs.analchem.2c02929, 10.26434/chemrxiv-2022-dp639

Tags

through space multinuclear magnetic resonance signal enhancement parahydrogen; radio frequency amplification stimulated emission radiation; hyperpolarized nuclear spin

Authors

Salnikov Oleg G. ^1,2 , Trofimov Ivan A. ^1,3 , Pravdivtsev Andrey N. ⁴ , Them Kolja ⁴ , Hövener Jan-Bernd ⁴ , Chekmenev Eduard Y. ^5,6 , Koptyug Igor V. ¹

Affiliations

1	International Tomography Center SB RAS, 3A Institutskaya St., 630090 Novosibirsk, Russia
2	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., 630090 Novosibirsk, Russia
3	Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk, Russia
4	Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein and Kiel University, 24118 Kiel, Germany
5	Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202, United States
6	Russian Academy of Sciences, 14 Leninskiy Pr., 119991 Moscow, Russia

Funding (19)

1	National Institutes of Health	1R21CA220137
2	European Commission	122-09-053
3	National Science Foundation	CHE-1904780
4	Russian Foundation for Basic Research	19-33-60045
5	National Institutes of Health	1R21HL154032-01
6	National Institute of Biomedical Imaging and Bioengineering	1R01EB029829
7	United States Department of Defense	W81XWH-20-10576
8	German Research Foundation	GRK 2154/1-2019
9	Federal Ministry of Education and Research	01ZX1915C
10	Russian Science Foundation	21-73-10105 (121121600301-4)
11	Council for Grants of the President of the Russian Federation	МК-2826.2022.1.3
12	German Research Foundation	SFB 1479
13	German Research Foundation	TRR287
14	German Research Foundation	HO 4602/2-2
15	German Research Foundation	HO 4602/3
16	German Research Foundation	PR1868/3-1
17	German Research Foundation	EXC2167
18	German Research Foundation	FOR5042
19	Ministry of Science and Higher Education of the Russian Federation

Hyperpolarized (i.e., polarized far beyond the thermal equilibrium) nuclear spins can result in the radiofrequency amplification by stimulated emission of radiation (RASER) effect. Here, we show the utility of RASER to amplify nuclear magnetic resonance (NMR) signals of solute and solvent molecules in the liquid state. Specifically, parahydrogen-induced RASER was used to spontaneously enhance nuclear spin polarization of protons and heteronuclei (here 19F and 31P) in a wide range of molecules. The magnitude of the effect correlates with the T1 relaxation time of the target nuclear spins. A series of control experiments validate the through-space dipolar mechanism of the RASER-assisted polarization transfer between the parahydrogen-polarized compound and to-be-hyperpolarized nuclei of the target molecule. Frequency-selective saturation of the RASER-active resonances was used to control the RASER and the amplitude of spontaneous polarization transfer. Spin dynamics simulations support our experimental RASER studies. The enhanced NMR sensitivity may benefit various NMR applications such as mixture analysis, metabolomics, and structure determination.

Salnikov O.G. , Trofimov I.A. , Pravdivtsev A.N. , Them K. , Hövener J-B. , Chekmenev E.Y. , Koptyug I.V.
Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation
Analytical Chemistry. 2022. V.94. N43. P.15010-15017. DOI: 10.1021/acs.analchem.2c02929, 10.26434/chemrxiv-2022-dp639 WOS Scopus РИНЦ AN PMID OpenAlex

Submitted:	Jul 7, 2022
Accepted:	Oct 7, 2022
Published online:	Oct 20, 2022
Published print:	Nov 1, 2022

Web of science:	WOS:000888011300001
Scopus:	2-s2.0-85141743110
Elibrary:	54731934
Chemical Abstracts:	2022:2663707
PMID:	36264746
OpenAlex:	W4306893554

DB	Citing
Scopus	17
Web of science	16
OpenAlex	18
Elibrary	16