Interplay of Cellular mRNA, miRNA and Viral miRNA during Infection of a Cell Научная публикация
| Журнал |
International Journal of Molecular Sciences
ISSN: 1422-0067 , E-ISSN: 1661-6596 |
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| Вых. Данные | Год: 2023, Том: 24, Номер: 1, Номер статьи : 122, Страниц : 15 DOI: 10.3390/ijms24010122 | ||
| Ключевые слова | intracellular viral kinetics; gene expression; mRNA and miRNA; mean-field kinetic equations; Monte Carlo simulations | ||
| Авторы |
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| Организации |
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Информация о финансировании (1)
| 1 | Министерство науки и высшего образования Российской Федерации (с 15 мая 2018) | 0239-2021-0009 |
Реферат:
The understanding of the kinetics of gene expression in cells infected by viruses is currently limited. As a rule, the corresponding models do not take viral microRNAs (miRNAs) into account. Such RNAs are, however, operative during the replication of some viruses, including, e.g., herpesvirus. To clarify the kinetics of this category (with emphasis on the information available for herpesvirus), I introduce a generic model describing the transient interplay of cellular mRNA, protein, miRNA and viral miRNA. In the absence of viral miRNA, the cellular miRNA is considered to suppress the populations of mRNA and protein due to association with mRNA and subsequent degradation. During infection, the viral miRNA suppresses the population of cellular miRNA and via this pathway makes the mRNA and protein populations larger. This effect becomes appreciable with the progress of intracellular viral replication. Using biologically reasonable parameters, I investigate the corresponding mean-field kinetics and show the scale of the effect of viral miRNAs on cellular miRNA and mRNA. The scale of fluctuations of the populations of these species is illustrated as well by employing Monte Carlo simulations.
Библиографическая ссылка:
Zhdanov V.P.
Interplay of Cellular mRNA, miRNA and Viral miRNA during Infection of a Cell
International Journal of Molecular Sciences. 2023. V.24. N1. 122 :1-15. DOI: 10.3390/ijms24010122 WOS Scopus РИНЦ CAPlusCA PMID OpenAlex
Interplay of Cellular mRNA, miRNA and Viral miRNA during Infection of a Cell
International Journal of Molecular Sciences. 2023. V.24. N1. 122 :1-15. DOI: 10.3390/ijms24010122 WOS Scopus РИНЦ CAPlusCA PMID OpenAlex
Даты:
| Поступила в редакцию: | 22 окт. 2022 г. |
| Принята к публикации: | 15 дек. 2022 г. |
| Опубликована online: | 21 дек. 2022 г. |
| Опубликована в печати: | 1 янв. 2023 г. |
Идентификаторы БД:
| Web of science: | WOS:000909604600001 |
| Scopus: | 2-s2.0-85145885837 |
| РИНЦ: | 54110351 |
| Chemical Abstracts: | 2023:99978 |
| Chemical Abstracts (print): | 181:348688 |
| PMID (PubMed): | 36613566 |
| OpenAlex: | W4312187403 |