Interplay of Cellular mRNA, miRNA and Viral miRNA during Infection of a Cell Full article
| Journal |
International Journal of Molecular Sciences
ISSN: 1422-0067 , E-ISSN: 1661-6596 |
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| Output data | Year: 2023, Volume: 24, Number: 1, Article number : 122, Pages count : 15 DOI: 10.3390/ijms24010122 | ||
| Tags | intracellular viral kinetics; gene expression; mRNA and miRNA; mean-field kinetic equations; Monte Carlo simulations | ||
| Authors |
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| Affiliations |
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Funding (1)
| 1 | Ministry of Science and Higher Education of the Russian Federation | 0239-2021-0009 |
Abstract:
The understanding of the kinetics of gene expression in cells infected by viruses is currently limited. As a rule, the corresponding models do not take viral microRNAs (miRNAs) into account. Such RNAs are, however, operative during the replication of some viruses, including, e.g., herpesvirus. To clarify the kinetics of this category (with emphasis on the information available for herpesvirus), I introduce a generic model describing the transient interplay of cellular mRNA, protein, miRNA and viral miRNA. In the absence of viral miRNA, the cellular miRNA is considered to suppress the populations of mRNA and protein due to association with mRNA and subsequent degradation. During infection, the viral miRNA suppresses the population of cellular miRNA and via this pathway makes the mRNA and protein populations larger. This effect becomes appreciable with the progress of intracellular viral replication. Using biologically reasonable parameters, I investigate the corresponding mean-field kinetics and show the scale of the effect of viral miRNAs on cellular miRNA and mRNA. The scale of fluctuations of the populations of these species is illustrated as well by employing Monte Carlo simulations.
Cite:
Zhdanov V.P.
Interplay of Cellular mRNA, miRNA and Viral miRNA during Infection of a Cell
International Journal of Molecular Sciences. 2023. V.24. N1. 122 :1-15. DOI: 10.3390/ijms24010122 WOS Scopus РИНЦ ANCAN PMID OpenAlex
Interplay of Cellular mRNA, miRNA and Viral miRNA during Infection of a Cell
International Journal of Molecular Sciences. 2023. V.24. N1. 122 :1-15. DOI: 10.3390/ijms24010122 WOS Scopus РИНЦ ANCAN PMID OpenAlex
Dates:
| Submitted: | Oct 22, 2022 |
| Accepted: | Dec 15, 2022 |
| Published online: | Dec 21, 2022 |
| Published print: | Jan 1, 2023 |
Identifiers:
| Web of science: | WOS:000909604600001 |
| Scopus: | 2-s2.0-85145885837 |
| Elibrary: | 54110351 |
| Chemical Abstracts: | 2023:99978 |
| Chemical Abstracts (print): | 181:348688 |
| PMID: | 36613566 |
| OpenAlex: | W4312187403 |