Activated Carbon-Enriched Electrospun-Produced Scaffolds for Drug Delivery/Release in Biological Systems | Sciact - CRIS-система Института катализа

Activated Carbon-Enriched Electrospun-Produced Scaffolds for Drug Delivery/Release in Biological Systems Научная публикация

Журнал

International Journal of Molecular Sciences
ISSN: 1422-0067 , E-ISSN: 1661-6596

Вых. Данные

Год: 2023, Том: 24, Номер: 7, Номер статьи : 6713, Страниц : 15 DOI: 10.3390/ijms24076713

Ключевые слова

activated carbon; controlled release; drug delivery; electrospinning; sirolimus

Авторы

Nazarkina Zhanna K. ¹ , Stepanova Alena O. ^1,2 , Chelobanov Boris P. ^1,3 , Kvon Ren I. ⁴ , Simonov Pavel A. ³ , Karpenko Andrey A. ² , Laktionov Pavel P. ^1,2

Организации

1	Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia
2	Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, 630055 Novosibirsk, Russia
3	Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia
4	Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia

Информация о финансировании (2)

1	Министерство науки и высшего образования Российской Федерации (с 15 мая 2018)	075-00404-21-00 (121031300042-1)
2	Министерство здравоохранения Росcийской Федерации	056-00125-21-00 AVRB-2021-0001 (121032300337-5)

To vectorize drug delivery from electrospun-produced scaffolds, we introduce a thin outer drug retention layer produced by electrospinning from activated carbon nanoparticles (ACNs)-enriched polycaprolacton (PCL) suspension. Homogeneous or coaxial fibers filled with ACNs were produced by electrospinning from different PCL-based suspensions. Stable ACN suspensions were selected by sorting through solvents, stabilizers and auxiliary components. The ACN-enriched scaffolds produced were characterized for fiber diameter, porosity, pore size and mechanical properties. The scaffold structure was analyzed by scanning electron microscopy and X-ray photoelectron spectroscopy. It was found that ACNs were mainly coated with a polymer layer for both homogeneous and coaxial fibers. Drug binding and release from the scaffolds were tested using tritium-labeled sirolimus. We showed that the kinetics of sirolimus binding/release by ACN-enriched scaffolds was determined by the fiber composition and differed from that obtained with a free ACN. ACN-enriched scaffolds with coaxial and homogeneous fibers had a biocompatibility close to scaffold-free AC, as was shown by the cultivation of human gingival fibroblasts and umbilical vein cells on scaffolds. The data obtained demonstrated that ACN-enriched scaffolds had good physico-chemical properties and biocompatibility and, thus, could be used as a retaining layer for vectored drug delivery.

Nazarkina Z.K. , Stepanova A.O. , Chelobanov B.P. , Kvon R.I. , Simonov P.A. , Karpenko A.A. , Laktionov P.P.
Activated Carbon-Enriched Electrospun-Produced Scaffolds for Drug Delivery/Release in Biological Systems
International Journal of Molecular Sciences. 2023. V.24. N7. 6713 :1-15. DOI: 10.3390/ijms24076713 WOS Scopus РИНЦ CAPlus PMID OpenAlex

Поступила в редакцию:	10 мар. 2023 г.
Принята к публикации:	1 апр. 2023 г.
Опубликована в печати:	1 апр. 2023 г.
Опубликована online:	4 апр. 2023 г.

Web of science:	WOS:000970207300001
Scopus:	2-s2.0-85152323651
РИНЦ:	53235879
Chemical Abstracts:	2023:810305
PMID (PubMed):	37047685
OpenAlex:	W4362559320

БД	Цитирований
Scopus	6
Web of science	4
РИНЦ	4
OpenAlex	7