Activated Carbon-Enriched Electrospun-Produced Scaffolds for Drug Delivery/Release in Biological Systems | Sciact - CRIS-system of Boreskov Institute of Catalysis

Activated Carbon-Enriched Electrospun-Produced Scaffolds for Drug Delivery/Release in Biological Systems Full article

Journal

International Journal of Molecular Sciences
ISSN: 1422-0067 , E-ISSN: 1661-6596

Output data

Year: 2023, Volume: 24, Number: 7, Article number : 6713, Pages count : 15 DOI: 10.3390/ijms24076713

Tags

activated carbon; controlled release; drug delivery; electrospinning; sirolimus

Authors

Nazarkina Zhanna K. ¹ , Stepanova Alena O. ^1,2 , Chelobanov Boris P. ^1,3 , Kvon Ren I. ⁴ , Simonov Pavel A. ³ , Karpenko Andrey A. ² , Laktionov Pavel P. ^1,2

Affiliations

1	Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia
2	Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, 630055 Novosibirsk, Russia
3	Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia
4	Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia

Funding (2)

1	Ministry of Science and Higher Education of the Russian Federation	075-00404-21-00 (121031300042-1)
2	Ministry of Health of the Russian Federation	056-00125-21-00 AVRB-2021-0001 (121032300337-5)

To vectorize drug delivery from electrospun-produced scaffolds, we introduce a thin outer drug retention layer produced by electrospinning from activated carbon nanoparticles (ACNs)-enriched polycaprolacton (PCL) suspension. Homogeneous or coaxial fibers filled with ACNs were produced by electrospinning from different PCL-based suspensions. Stable ACN suspensions were selected by sorting through solvents, stabilizers and auxiliary components. The ACN-enriched scaffolds produced were characterized for fiber diameter, porosity, pore size and mechanical properties. The scaffold structure was analyzed by scanning electron microscopy and X-ray photoelectron spectroscopy. It was found that ACNs were mainly coated with a polymer layer for both homogeneous and coaxial fibers. Drug binding and release from the scaffolds were tested using tritium-labeled sirolimus. We showed that the kinetics of sirolimus binding/release by ACN-enriched scaffolds was determined by the fiber composition and differed from that obtained with a free ACN. ACN-enriched scaffolds with coaxial and homogeneous fibers had a biocompatibility close to scaffold-free AC, as was shown by the cultivation of human gingival fibroblasts and umbilical vein cells on scaffolds. The data obtained demonstrated that ACN-enriched scaffolds had good physico-chemical properties and biocompatibility and, thus, could be used as a retaining layer for vectored drug delivery.

Nazarkina Z.K. , Stepanova A.O. , Chelobanov B.P. , Kvon R.I. , Simonov P.A. , Karpenko A.A. , Laktionov P.P.
Activated Carbon-Enriched Electrospun-Produced Scaffolds for Drug Delivery/Release in Biological Systems
International Journal of Molecular Sciences. 2023. V.24. N7. 6713 :1-15. DOI: 10.3390/ijms24076713 WOS Scopus РИНЦ AN PMID OpenAlex

Submitted:	Mar 10, 2023
Accepted:	Apr 1, 2023
Published print:	Apr 1, 2023
Published online:	Apr 4, 2023

Web of science:	WOS:000970207300001
Scopus:	2-s2.0-85152323651
Elibrary:	53235879
Chemical Abstracts:	2023:810305
PMID:	37047685
OpenAlex:	W4362559320

DB	Citing
Scopus	6
Web of science	4
Elibrary	4
OpenAlex	7