Реферат: Some neurological disorders such e.g. as Alzheimer disease are accompanied by the appearance of amyloid fibrils inside and outside cells. Herein, I present a generic coarse-grained kinetic mean-field model describing at the extracellular level the interplay of fibrils and cells. It includes the formation and degradation of fibrils, activation of healthy cells with respect to the fabrication of fibrils, and death of activated cells. The corresponding analysis indicates that the disease development can occur in two qualitatively different regimes. The first one is controlled primarily by the intrinsic factors resulting in slow increase of fibril production inside cells. The second one implies faster self-promoted growth of the fibril population by analogy with explosion. This prediction reported as a hypothesis is of interest for conceptual understanding of the neurological disorders.

Библиографическая ссылка: Zhdanov V.P.
Extracellular Interplay of Amyloid Fibrils and Neural Cells
Biosystems. 2023. V.231. 104971 :1-4. DOI: 10.1016/j.biosystems.2023.104971 WOS Scopus РИНЦ CAPlus PMID OpenAlex

Даты:

Поступила в редакцию:	17 апр. 2023 г.
Принята к публикации:	3 июл. 2023 г.
Опубликована online:	8 июл. 2023 г.
Опубликована в печати:	1 сент. 2023 г.

Идентификаторы БД:

Web of science:	WOS:001058833900001
Scopus:	2-s2.0-85166205489
РИНЦ:	54368720
Chemical Abstracts:	2023:1682053
PMID (PubMed):	37429375
OpenAlex:	W4383646275

Цитирование в БД: Пока нет цитирований

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