Extracellular Interplay of Amyloid Fibrils and Neural Cells | Sciact - CRIS-system of Boreskov Institute of Catalysis

Extracellular Interplay of Amyloid Fibrils and Neural Cells Full article

Journal

Biosystems
ISSN: 0303-2647 , E-ISSN: 1872-8324

Output data

Year: 2023, Volume: 231, Article number : 104971, Pages count : 4 DOI: 10.1016/j.biosystems.2023.104971

Tags

Neurology; Alzheimer disease; Amyloid fibrils; Plagued cells; Kinetic model; Kinetic regimes

Authors

Zhdanov Vladimir P. ^1,2

Affiliations

1	Section of Nano and Biophysics, Department of Physics, Chalmers University of Technology, Göteborg, Sweden
2	Boreskov Institute of Catalysis, Russian Academy of Sciences, Novosibirsk, Russia

Some neurological disorders such e.g. as Alzheimer disease are accompanied by the appearance of amyloid fibrils inside and outside cells. Herein, I present a generic coarse-grained kinetic mean-field model describing at the extracellular level the interplay of fibrils and cells. It includes the formation and degradation of fibrils, activation of healthy cells with respect to the fabrication of fibrils, and death of activated cells. The corresponding analysis indicates that the disease development can occur in two qualitatively different regimes. The first one is controlled primarily by the intrinsic factors resulting in slow increase of fibril production inside cells. The second one implies faster self-promoted growth of the fibril population by analogy with explosion. This prediction reported as a hypothesis is of interest for conceptual understanding of the neurological disorders.

Zhdanov V.P.
Extracellular Interplay of Amyloid Fibrils and Neural Cells
Biosystems. 2023. V.231. 104971 :1-4. DOI: 10.1016/j.biosystems.2023.104971 WOS Scopus РИНЦ AN PMID OpenAlex

Submitted:	Apr 17, 2023
Accepted:	Jul 3, 2023
Published online:	Jul 8, 2023
Published print:	Sep 1, 2023

Web of science:	WOS:001058833900001
Scopus:	2-s2.0-85166205489
Elibrary:	54368720
Chemical Abstracts:	2023:1682053
PMID:	37429375
OpenAlex:	W4383646275

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