Реферат: Hyperpolarized magnetic resonance imaging (MRI) contrast agents are revolutionizing the field of biomedical imaging. Hyperpolarized Xe-129 was recently FDA approved as an inhalable MRI contrast agent for functional lung imaging sensing. Despite success in research settings, modern Xe-129 hyperpolarizers are expensive (up to $1M), large, and complex to site and operate. Moreover, Xe-129 sensing requires specialized MRI hardware that is not commonly available on clinical MRI scanners. Here, we demonstrate that proton-hyperpolarized propane gas can be produced on demand using a disposable, hand-held, clinical-scale hyperpolarizer via parahydrogen-induced polarization, which relies on parahydrogen as a source of hyperpolarization. The device consists of a heterogeneous catalytic reactor connected to a gas mixture storage can containing pressurized hyperpolarization precursors: propylene and parahydrogen (10 bar total pressure). Once the built-in flow valve of the storage can is actuated, the precursors are ejected from the can into a reactor, and a stream of hyperpolarized propane gas is ejected from the reactor. Robust operation of the device is demonstrated for producing proton sensing polarization of 1.2% in a wide range of operational pressures and gas flow rates. We demonstrate that the propylene/parahydrogen gas mixture can retain potency for days in the storage can with a monoexponential decay time constant of 6.0 ± 0.5 days, which is limited by the lifetime of the parahydrogen singlet spin state in the storage container. The utility of the produced sensing agent is demonstrated for phantom imaging on a 3 T clinical MRI scanner located 100 miles from the agent/device preparation site and also for ventilation imaging of excised pig lungs using a 0.35 T clinical MRI scanner. The cost of the device components is less than $35, which we envision can be reduced to less than $5 for mass-scale production. The hyperpolarizer device can be reused, recycled, or disposed.

Библиографическая ссылка: Ariyasingha N.M. , Samoilenko A. , Birchall J.R. , Chowdhury M.R.H. , Salnikov O.G. , Kovtunova L.M. , Bukhtiyarov V.I. , Zhu D.C. , Qian C. , Bradley M. , Gelovani J.G. , Koptyug I.V. , Goodson B.M. , Chekmenev E.Y.
Ultra-Low-Cost Disposable Hand-Held Clinical-Scale Propane Gas Hyperpolarizer for Pulmonary Magnetic Resonance Imaging Sensing
ACS Sensors. 2023. V.8. N10. P.3845–3854. DOI: 10.1021/acssensors.3c01369 WOS Scopus РИНЦ CAPlus PMID OpenAlex

Даты:

Поступила в редакцию:	6 июл. 2023 г.
Принята к публикации:	6 сент. 2023 г.
Опубликована online:	29 сент. 2023 г.
Опубликована в печати:	27 окт. 2023 г.

Идентификаторы БД:

Web of science:	WOS:001076039900001
Scopus:	2-s2.0-85174908517
РИНЦ:	55253995
Chemical Abstracts:	2023:2009766
PMID (PubMed):	37772716
OpenAlex:	W4387157568

Цитирование в БД:

БД	Цитирований
OpenAlex	8
Web of science	8
Scopus	8
РИНЦ	7

Альметрики: