Ultra-Low-Cost Disposable Hand-Held Clinical-Scale Propane Gas Hyperpolarizer for Pulmonary Magnetic Resonance Imaging Sensing Full article
| Journal |
ACS Sensors
ISSN: 2379-3694 |
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| Output data | Year: 2023, Volume: 8, Number: 10, Pages: 3845–3854 Pages count : 10 DOI: 10.1021/acssensors.3c01369 | ||||||||||||||||||
| Tags | MRI, hyperpolarization, imaging agents, NMR spectroscopy, parahydrogen, propane | ||||||||||||||||||
| Authors |
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| Affiliations |
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Funding (7)
| 1 | United States Department of Defense | W81XWH-20-10576 |
| 2 | United States Department of Defense | W81XWH-20-10578 |
| 3 | National Science Foundation | CHE-1905341 |
| 4 | National Science Foundation | CHE-1904780 |
| 5 | National Institutes of Health | 1R21HL154032-01 |
| 6 | National Heart Lung and Blood Institute | 1F32HL160108 |
| 7 | Ministry of Science and Higher Education of the Russian Federation | 075-15-2020-779 |
Abstract:
Hyperpolarized magnetic resonance imaging (MRI) contrast agents are revolutionizing the field of biomedical imaging. Hyperpolarized Xe-129 was recently FDA approved as an inhalable MRI contrast agent for functional lung imaging sensing. Despite success in research settings, modern Xe-129 hyperpolarizers are expensive (up to $1M), large, and complex to site and operate. Moreover, Xe-129 sensing requires specialized MRI hardware that is not commonly available on clinical MRI scanners. Here, we demonstrate that proton-hyperpolarized propane gas can be produced on demand using a disposable, hand-held, clinical-scale hyperpolarizer via parahydrogen-induced polarization, which relies on parahydrogen as a source of hyperpolarization. The device consists of a heterogeneous catalytic reactor connected to a gas mixture storage can containing pressurized hyperpolarization precursors: propylene and parahydrogen (10 bar total pressure). Once the built-in flow valve of the storage can is actuated, the precursors are ejected from the can into a reactor, and a stream of hyperpolarized propane gas is ejected from the reactor. Robust operation of the device is demonstrated for producing proton sensing polarization of 1.2% in a wide range of operational pressures and gas flow rates. We demonstrate that the propylene/parahydrogen gas mixture can retain potency for days in the storage can with a monoexponential decay time constant of 6.0 ± 0.5 days, which is limited by the lifetime of the parahydrogen singlet spin state in the storage container. The utility of the produced sensing agent is demonstrated for phantom imaging on a 3 T clinical MRI scanner located 100 miles from the agent/device preparation site and also for ventilation imaging of excised pig lungs using a 0.35 T clinical MRI scanner. The cost of the device components is less than $35, which we envision can be reduced to less than $5 for mass-scale production. The hyperpolarizer device can be reused, recycled, or disposed.
Cite:
Ariyasingha N.M.
, Samoilenko A.
, Birchall J.R.
, Chowdhury M.R.H.
, Salnikov O.G.
, Kovtunova L.M.
, Bukhtiyarov V.I.
, Zhu D.C.
, Qian C.
, Bradley M.
, Gelovani J.G.
, Koptyug I.V.
, Goodson B.M.
, Chekmenev E.Y.
Ultra-Low-Cost Disposable Hand-Held Clinical-Scale Propane Gas Hyperpolarizer for Pulmonary Magnetic Resonance Imaging Sensing
ACS Sensors. 2023. V.8. N10. P.3845–3854. DOI: 10.1021/acssensors.3c01369 WOS Scopus РИНЦ AN PMID OpenAlex
Ultra-Low-Cost Disposable Hand-Held Clinical-Scale Propane Gas Hyperpolarizer for Pulmonary Magnetic Resonance Imaging Sensing
ACS Sensors. 2023. V.8. N10. P.3845–3854. DOI: 10.1021/acssensors.3c01369 WOS Scopus РИНЦ AN PMID OpenAlex
Dates:
| Submitted: | Jul 6, 2023 |
| Accepted: | Sep 6, 2023 |
| Published online: | Sep 29, 2023 |
| Published print: | Oct 27, 2023 |
Identifiers:
| Web of science: | WOS:001076039900001 |
| Scopus: | 2-s2.0-85174908517 |
| Elibrary: | 55253995 |
| Chemical Abstracts: | 2023:2009766 |
| PMID: | 37772716 |
| OpenAlex: | W4387157568 |