Discovery of New Ginsenol-Like Compounds with High Antiviral Activity | Sciact - CRIS-система Института катализа

Discovery of New Ginsenol-Like Compounds with High Antiviral Activity Научная публикация

Журнал

Molecules
ISSN: 1420-3049

Вых. Данные

Год: 2021, Том: 26, Номер: 22, Номер статьи : 6794, Страниц : 23 DOI: 10.3390/molecules26226794

Ключевые слова

Ginsenol; Ginsamide; antiviral agent; surface protein; influenza; resistance; molecular modeling

Авторы

Volobueva Aleksandrina S. ¹ , Yarovaya Olga I. ² , Kireeva Marina V. ³ , Borisevich Sophia S. ⁴ , Kovaleva Kseniya S. ² , Mainagashev Iliya Ya. ² , Gatilov Yuri V. ² , Ilyina Margarita G. ⁴ , Zarubaev Vladimir V. ¹ , Salakhutdinov Nariman F. ²

Организации

1	Laboratory of Experimental Virology Pasteur Institute of Epidemiology and Microbiology, 14 Mira Str., 197101 St. Petersburg, Russia
2	Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia
3	Biology Department, St. Petersburg State University, 7/9 Universitetskaya Nab., 199034 St. Petersburg, Russia
4	Laboratory of Chemical Physics, Ufa Institute of Chemistry Ufa Federal Research Center, 71 Pr. Oktyabrya, 450078 Ufa, Russia

A number of framework amides with a ginsenol backbone have been synthesized using the Ritter reaction. We named the acetamide as Ginsamide. A method was developed for the synthesis of the corresponding amine and thioacetamide. The new compounds revealed a high activity against H1N1 influenza, which was confirmed using an animal model. Biological experiments were performed to determine the mechanism of action of the new agents, a ginsamide-resistant strain of influenza virus was obtained, and the pathogenicity of the resistant strain and the control strain was studied. It was shown that the emergence of resistance to Ginsamide was accompanied by a reduction in the pathogenicity of the influenza virus.

Volobueva A.S. , Yarovaya O.I. , Kireeva M.V. , Borisevich S.S. , Kovaleva K.S. , Mainagashev I.Y. , Gatilov Y.V. , Ilyina M.G. , Zarubaev V.V. , Salakhutdinov N.F.
Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
Molecules. 2021. V.26. N22. 6794 :1-23. DOI: 10.3390/molecules26226794 WOS Scopus OpenAlex

Поступила в редакцию:	18 окт. 2021 г.
Принята к публикации:	6 нояб. 2021 г.
Опубликована в печати:	10 нояб. 2021 г.
Опубликована online:	10 нояб. 2021 г.

Web of science:	WOS:000815305600001
Scopus:	2-s2.0-85119589192
OpenAlex:	W3212583477

БД	Цитирований
OpenAlex	13
Web of science	9
Scopus	9