Discovery of New Ginsenol-Like Compounds with High Antiviral Activity | Sciact - CRIS-system of Boreskov Institute of Catalysis

Discovery of New Ginsenol-Like Compounds with High Antiviral Activity Full article

Journal

Molecules
ISSN: 1420-3049

Output data

Year: 2021, Volume: 26, Number: 22, Article number : 6794, Pages count : 23 DOI: 10.3390/molecules26226794

Tags

Ginsenol; Ginsamide; antiviral agent; surface protein; influenza; resistance; molecular modeling

Authors

Volobueva Aleksandrina S. ¹ , Yarovaya Olga I. ² , Kireeva Marina V. ³ , Borisevich Sophia S. ⁴ , Kovaleva Kseniya S. ² , Mainagashev Iliya Ya. ² , Gatilov Yuri V. ² , Ilyina Margarita G. ⁴ , Zarubaev Vladimir V. ¹ , Salakhutdinov Nariman F. ²

Affiliations

1	Laboratory of Experimental Virology Pasteur Institute of Epidemiology and Microbiology, 14 Mira Str., 197101 St. Petersburg, Russia
2	Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia
3	Biology Department, St. Petersburg State University, 7/9 Universitetskaya Nab., 199034 St. Petersburg, Russia
4	Laboratory of Chemical Physics, Ufa Institute of Chemistry Ufa Federal Research Center, 71 Pr. Oktyabrya, 450078 Ufa, Russia

A number of framework amides with a ginsenol backbone have been synthesized using the Ritter reaction. We named the acetamide as Ginsamide. A method was developed for the synthesis of the corresponding amine and thioacetamide. The new compounds revealed a high activity against H1N1 influenza, which was confirmed using an animal model. Biological experiments were performed to determine the mechanism of action of the new agents, a ginsamide-resistant strain of influenza virus was obtained, and the pathogenicity of the resistant strain and the control strain was studied. It was shown that the emergence of resistance to Ginsamide was accompanied by a reduction in the pathogenicity of the influenza virus.

Volobueva A.S. , Yarovaya O.I. , Kireeva M.V. , Borisevich S.S. , Kovaleva K.S. , Mainagashev I.Y. , Gatilov Y.V. , Ilyina M.G. , Zarubaev V.V. , Salakhutdinov N.F.
Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
Molecules. 2021. V.26. N22. 6794 :1-23. DOI: 10.3390/molecules26226794 WOS Scopus OpenAlex

Submitted:	Oct 18, 2021
Accepted:	Nov 6, 2021
Published print:	Nov 10, 2021
Published online:	Nov 10, 2021

Web of science:	WOS:000815305600001
Scopus:	2-s2.0-85119589192
OpenAlex:	W3212583477

DB	Citing
OpenAlex	13
Web of science	9
Scopus	10