Core-Shell Mechanocomposites of Drugs with Inorganic Oxides and Hydroxides | Sciact - CRIS-система Института катализа

Core-Shell Mechanocomposites of Drugs with Inorganic Oxides and Hydroxides Научная публикация

Конференция

12th Annual Conference YUCOMAT 2010
06-10 сент. 2010 , Herceg Novi

Журнал

Acta Physica Polonica A
ISSN: 0587-4246 , E-ISSN: 1898-794X

Вых. Данные

Год: 2014, Том: 126, Номер: 4, Страницы: 1019-1024 Страниц : 6 DOI: 10.12693/APhysPolA.126.1019

Ключевые слова

AluminaAluminum oxideBall millingCorundumDrug deliveryHematiteParticle sizePhotoelectron spectroscopyPyridineShells (structures)X ray photoelectron spectroscopy

Авторы

Shakhtshneider T.P. ^1,2 , Myz S.A. ^1,2 , Boldyreva E.V. ^1,2 , Nizovskii A.I. ^3,4 , Kumar Rakesh ⁵

Организации

1	Institute of Solid State Chemistry and Mechanochemistry, SB RAS, Kutateladze Str., 18, Novosibirsk, 630128, Russia
2	Novosibirsk State University, Pirogova Str., 2, Novosibirsk, 630090, Russia
3	Boreskov Institute of Catalysis, SB RAS, Pr. Lavrentieva, 5, Novosibirsk, 630090, Russia
4	Omsk State Technical University, Pr. Mira, 11, Omsk, 644050, Russia
5	National Metallurgical Laboratory, Jamshedpur, 831 007, India

Информация о финансировании (4)

1	Российский фонд фундаментальных исследований	13-03-92704
2	Президиум РАН
3	Department of Science and Technology
4	Российский фонд фундаментальных исследований	09-03-92658

The composites of piroxicam and meloxicam with gamma-alumina, aluminium hydroxides (gibbsite and boehmite), alpha and gamma polymorphs of iron(III) oxide having different surface area and morphology were prepared by planetary ball-milling. It has been shown that the initial state of the excipient (specific surface area, particle size and morphology) had a pronounced effect on the formation of the core-shell composites with the drugs and their properties. The X-ray diffraction patterns and IR spectra measured for co-milled samples as well as X-ray photoelectron spectroscopy studies gave evidence that the components of the mixtures interacted with each other and became amorphous, as composites were formed. The drug release from the composites was different as compared with pure drugs, meloxicam and piroxicam behaving differently that can be explained by formation of strong or weak bonds with the active sites of the carriers. In the case of mechanocomposites, the drugs dissolved quickly due to high surface of organic phase in the core-shell composites. The high-porous carriers can serve as the sorbents for the drugs in solution.

Shakhtshneider T.P. , Myz S.A. , Boldyreva E.V. , Nizovskii A.I. , Kumar R.
Core-Shell Mechanocomposites of Drugs with Inorganic Oxides and Hydroxides

Acta Physica Polonica A. 2014. V.126. N4. P.1019-1024. DOI: 10.12693/APhysPolA.126.1019 WOS Scopus РИНЦ CAPlus OpenAlex

Полный текст от издателя

Опубликована в печати:

1 окт. 2014 г.

Web of science:	WOS:000345860000036
Scopus:	2-s2.0-84911486878
РИНЦ:	24006548
Chemical Abstracts:	2015:57472
OpenAlex:	W2001459114

БД	Цитирований
Web of science	5
Scopus	5
РИНЦ	5
OpenAlex	5