Core-Shell Mechanocomposites of Drugs with Inorganic Oxides and Hydroxides | Sciact - CRIS-system of Boreskov Institute of Catalysis

Core-Shell Mechanocomposites of Drugs with Inorganic Oxides and Hydroxides Full article

Conference

12th Annual Conference YUCOMAT 2010
06-10 Sep 2010 , Herceg Novi

Journal

Acta Physica Polonica A
ISSN: 0587-4246 , E-ISSN: 1898-794X

Output data

Year: 2014, Volume: 126, Number: 4, Pages: 1019-1024 Pages count : 6 DOI: 10.12693/APhysPolA.126.1019

Tags

AluminaAluminum oxideBall millingCorundumDrug deliveryHematiteParticle sizePhotoelectron spectroscopyPyridineShells (structures)X ray photoelectron spectroscopy

Authors

Shakhtshneider T.P. ^1,2 , Myz S.A. ^1,2 , Boldyreva E.V. ^1,2 , Nizovskii A.I. ^3,4 , Kumar Rakesh ⁵

Affiliations

1	Institute of Solid State Chemistry and Mechanochemistry, SB RAS, Kutateladze Str., 18, Novosibirsk, 630128, Russia
2	Novosibirsk State University, Pirogova Str., 2, Novosibirsk, 630090, Russia
3	Boreskov Institute of Catalysis, SB RAS, Pr. Lavrentieva, 5, Novosibirsk, 630090, Russia
4	Omsk State Technical University, Pr. Mira, 11, Omsk, 644050, Russia
5	National Metallurgical Laboratory, Jamshedpur, 831 007, India

Funding (4)

1	Russian Foundation for Basic Research	13-03-92704
2	Президиум РАН
3	Department of Science and Technology
4	Russian Foundation for Basic Research	09-03-92658

The composites of piroxicam and meloxicam with gamma-alumina, aluminium hydroxides (gibbsite and boehmite), alpha and gamma polymorphs of iron(III) oxide having different surface area and morphology were prepared by planetary ball-milling. It has been shown that the initial state of the excipient (specific surface area, particle size and morphology) had a pronounced effect on the formation of the core-shell composites with the drugs and their properties. The X-ray diffraction patterns and IR spectra measured for co-milled samples as well as X-ray photoelectron spectroscopy studies gave evidence that the components of the mixtures interacted with each other and became amorphous, as composites were formed. The drug release from the composites was different as compared with pure drugs, meloxicam and piroxicam behaving differently that can be explained by formation of strong or weak bonds with the active sites of the carriers. In the case of mechanocomposites, the drugs dissolved quickly due to high surface of organic phase in the core-shell composites. The high-porous carriers can serve as the sorbents for the drugs in solution.

Shakhtshneider T.P. , Myz S.A. , Boldyreva E.V. , Nizovskii A.I. , Kumar R.
Core-Shell Mechanocomposites of Drugs with Inorganic Oxides and Hydroxides

Acta Physica Polonica A. 2014. V.126. N4. P.1019-1024. DOI: 10.12693/APhysPolA.126.1019 WOS Scopus РИНЦ AN OpenAlex

Full text from publisher

Published print:

Oct 1, 2014

Web of science:	WOS:000345860000036
Scopus:	2-s2.0-84911486878
Elibrary:	24006548
Chemical Abstracts:	2015:57472
OpenAlex:	W2001459114

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Web of science	5
Scopus	5
Elibrary	5
OpenAlex	5