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Evaluation of Properties for Carbothane™ 3575A–Based Electrospun Vascular Grafts in vitro and in vivo Научная публикация

Журнал Biomedical Materials
ISSN: 1748-605X
Вых. Данные Год: 2024, Том: 19, Номер: 6, Номер статьи : 065012, Страниц : DOI: 10.1088/1748-605x/ad792d
Ключевые слова Carbothane™ 3575A; electrospinning; endothelial human cells; functioning in vivo; hemocompatibility; polycarbonate-based polyurethane; small-diameter vascular graft.
Авторы Chernonosova Vera S. 1 , Osipova Olesia S. 2 , Nuankai Zhou 1 , Shundrina Inna K. 3 , Murashov Ivan S. 2 , Larichev Yurii V. 4 , Karpenko Andrey A. 2 , Laktionov Pavel P. 1
Организации
1 Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, Novosibirsk, Novosibirskaâ, 630090, RUSSIAN FEDERATION.
2 FSBI National Medical Research Center named after E N Meshalkin, Rechkunovskaya 15, Novosibirsk, None Selected, 630055, RUSSIAN FEDERATION.
3 Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrentieva Avenue 9, Novosibirsk, 630090, RUSSIAN FEDERATION.
4 Boreskov Institute of Catalysis SB RAS, Lavrentieva Avenue 5, Novosibirsk, 630090, RUSSIAN FEDERATION.

Реферат: Bioengineered vascular grafts have emerged as a promising alternative to the treatment of damaged or occlusive vessels. It is thought that polyurethane-based scaffolds possess suitable hemocompatibility and biomechanics comparable to those of normal blood vessels. In this study, we investigated the properties of electrospun scaffolds comprising various blends of biostable polycarbonate-based polyurethane (Carbothane™ 3575A) and gelatin. Scaffolds were characterized by scanning electron microscopy, infra-red spectroscopy, small-angle X-ray scattering, stress-loading tests, and interactions with primary human cells and blood. Data from in vitro experiments demonstrated that a scaffold produced from a blend of 5% Carbothane™ 3575A and 10% gelatin has proven to be a suitable material for fabricating a small-diameter vascular graft. A comparative in vivo study of such vascular grafts and ePTFE grafts implanted in the abdominal aorta of Wistar rats was performed. The data of intravital study and histological examination indicated that Carbothane-based electrospun grafts outclass ePTFE grafts and represent a promising device for preclinical studies to satisfy vascular surgery needs.
Библиографическая ссылка: Chernonosova V.S. , Osipova O.S. , Nuankai Z. , Shundrina I.K. , Murashov I.S. , Larichev Y.V. , Karpenko A.A. , Laktionov P.P.
Evaluation of Properties for Carbothane™ 3575A–Based Electrospun Vascular Grafts in vitro and in vivo
Biomedical Materials. 2024. V.19. N6. 065012 . DOI: 10.1088/1748-605x/ad792d WOS Scopus РИНЦ PMID OpenAlex
Даты:
Поступила в редакцию: 13 апр. 2024 г.
Принята к публикации: 10 сент. 2024 г.
Опубликована online: 10 сент. 2024 г.
Опубликована в печати: 1 нояб. 2024 г.
Идентификаторы БД:
Web of science: WOS:001317243000001
Scopus: 2-s2.0-85204660041
РИНЦ: 73859719
PMID (PubMed): 39255825
OpenAlex: W4402397827
Цитирование в БД:
БД Цитирований
OpenAlex 1
Web of science 1
Scopus 1
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