Rapid Lung Ventilation MRI Using Parahydrogen-Induced Polarization of Propane Gas | Sciact - CRIS-system of Boreskov Institute of Catalysis

Rapid Lung Ventilation MRI Using Parahydrogen-Induced Polarization of Propane Gas Full article

Journal

Analyst
ISSN: 0003-2654 , E-ISSN: 1364-5528

Output data

Year: 2024, Volume: 149, Number: 24, Pages: 5832-5842 Pages count : 11 DOI: 10.1039/d4an01029a

Tags

Induced polarization logging; Lung cancer; Nuclear magnetic resonance; Spin polarization

Authors

Chowdhury Md Raduanul H. ¹ , Oladun Clementinah ¹ , Ariyasingha Nuwandi M. ¹ , Samoilenko Anna ¹ , Bawardi Tarek ¹ , Burueva Dudari B. ² , Salnikov Oleg G. ² , Kovtunova Larisa M. ^3,2 , Bukhtiyarov Valerii I. ³ , Shi Zhongjie ⁴ , Luo Kehuan ⁴ , Tan Sidhartha ⁴ , Gelovani Juri G. ^1,5 , Koptyug Igor V. ² , Goodson Boyd M. ⁶ , Chekmenev Eduard Y. ¹

Affiliations

1	Department of Chemistry, Integrative Biosciences (Ibio), Wayne State University, Karmanos Cancer Institute (KCI), Detroit, Michigan 48202, USA
2	International Tomography Center, SB RAS, 3A Institutskaya St., Novosibirsk 630090, Russia
3	Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., Novosibirsk 630090, Russia
4	Department of Pediatrics, Wayne State University, Detroit, Michigan 48202, USA
5	United Arab Emirates University, Al Ain, United Arab Emirates
6	School of Chemical & Biomolecular Sciences, Materials Technology Center, Southern Illinois University, Carbondale, IL 62901, USA

Funding (12)

1	Ministry of Science and Higher Education of the Russian Federation	FWUR-2024-0032
2	Russian Science Foundation	23-23-00394
3	National Institutes of Health	R01NS130258
4	National Institutes of Health	R01NS117146
5	National Institutes of Health	R01NS114972
6	National Heart Lung and Blood Institute	1F32HL160108
7	National Institutes of Health	1R21HL154032-01
8	United States Department of Defense	W81XWH-20-10578
9	United States Department of Defense	W81XWH-20-10576
10	Ministry of Science and Higher Education of the Russian Federation
11	National Science Foundation	CHE–2404387
12	National Science Foundation	CHE-2404388

Proton-hyperpolarized contrast agents are attractive because they can be imaged on virtually any clinical MRI scanner, which is typically equipped to scan only protons rather than heteronuclei (i.e., anything besides protons, e.g., 13C, 15N, 129Xe, 23Na, etc.). Even though the lifetime of the proton spin hyperpolarization is only a few seconds, it is sufficient for inhalation and scanning of proton-hyperpolarized gas media. We demonstrate the utility of producing hyperpolarized propane gas via heterogeneous parahydrogen-induced polarization for the purpose of ventilation imaging in an excised rabbit lung model. The magnetization of protons in hyperpolarized propane gas is similar to that of tissue water protons, making it possible to rapidly perform lung ventilation imaging with a 0.35 T clinical MRI scanner. Here, we demonstrate the feasibility of rapid (2 s) lung ventilation MRI in excised rabbit lungs using hyperpolarized propane gas with a 1 × 1 mm2 pixel size using a 50 mm slice thickness, and a 1.7 × 1.7 mm2 pixel size using a 9 mm slice thickness.

Chowdhury M.R.H. , Oladun C. , Ariyasingha N.M. , Samoilenko A. , Bawardi T. , Burueva D.B. , Salnikov O.G. , Kovtunova L.M. , Bukhtiyarov V.I. , Shi Z. , Luo K. , Tan S. , Gelovani J.G. , Koptyug I.V. , Goodson B.M. , Chekmenev E.Y.
Rapid Lung Ventilation MRI Using Parahydrogen-Induced Polarization of Propane Gas
Analyst. 2024. V.149. N24. P.5832-5842. DOI: 10.1039/d4an01029a WOS Scopus AN PMID OpenAlex

Submitted:	Jul 29, 2024
Accepted:	Oct 22, 2024
Published online:	Nov 12, 2024
Published print:	Dec 21, 2024

Web of science:	WOS:001352287100001
Scopus:	2-s2.0-85208809841
Chemical Abstracts:	2024:2480016
PMID:	39530397
OpenAlex:	W4404279004

DB	Citing
Web of science	2
Scopus	4
OpenAlex	3