Kinetic Model of Receptor-Mediated Adhesion of Cells to a Functionalized Supported Lipid Bilayer Full article
Journal |
Chemical Physics Letters
ISSN: 0009-2614 , E-ISSN: 1873-4448 |
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Output data | Year: 2007, Volume: 448, Number: 4-6, Pages: 268-272 Pages count : 5 DOI: 10.1016/j.cplett.2007.10.010 | ||||
Tags | Bonding; Diffusion; Ligands; Lipid bilayers; Reaction kinetics | ||||
Authors |
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Affiliations |
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Funding (3)
1 | Swedish Research Council | |
2 | Stiftelsen för strategisk forskning | |
3 | European Commission | 505868 FP6-2002-NMP-1 STREP NANOCUES |
Abstract:
We present a kinetic model describing adhesion of cells to a supported lipid bilayer due to formation of bonds between cellular receptors and ligands (e.g., peptides or proteins) attached to the bilayer. The model implies a power-law dependence of the adhesion rate on the ligand concentration and takes into account ligand diffusion and association with already adhered cells. For a time interval longer than the sedimentation time, it predicts a sigmoidal dependence of the population of adhered cells on the initial ligand concentration. This feature becomes less pronounced with increasing rate of ligand association with adhered cells. The results obtained are used to interpret recent experiments with rat adult neural progenitor cells.
Cite:
Zhdanov V.P.
, Kasemo B.
Kinetic Model of Receptor-Mediated Adhesion of Cells to a Functionalized Supported Lipid Bilayer
Chemical Physics Letters. 2007. V.448. N4-6. P.268-272. DOI: 10.1016/j.cplett.2007.10.010 WOS Scopus РИНЦ
Kinetic Model of Receptor-Mediated Adhesion of Cells to a Functionalized Supported Lipid Bilayer
Chemical Physics Letters. 2007. V.448. N4-6. P.268-272. DOI: 10.1016/j.cplett.2007.10.010 WOS Scopus РИНЦ
Dates:
Submitted: | Jun 27, 2007 |
Accepted: | Oct 4, 2007 |
Published online: | Oct 9, 2007 |
Published print: | Nov 14, 2007 |
Identifiers:
Web of science | WOS:000251408300024 |
Scopus | 2-s2.0-35648979436 |
Elibrary | 13549614 |
Chemical Abstracts | 2007:1254248 |
Chemical Abstracts (print) | 148:95035 |
OpenAlex | W2041265455 |
Citing:
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