Transient Stochastic Bistable Kinetics of Gene Transcription During the Cellular Growth Full article
Journal |
Chemical Physics Letters
ISSN: 0009-2614 , E-ISSN: 1873-4448 |
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Output data | Year: 2006, Volume: 424, Number: 4-6, Pages: 394-398 Pages count : 5 DOI: 10.1016/j.cplett.2006.05.024 | ||||
Tags | Genes; Growth kinetics; Monte Carlo methods; Proteins; RNA | ||||
Authors |
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Affiliations |
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Funding (3)
1 | Swedish Research Council | |
2 | Stiftelsen för strategisk forskning | |
3 | European Commission | 505868 FP6-2002-NMP-1 STREP NANOCUES |
Abstract:
The feedback between mRNA and regulatory-protein production may result in bistability of gene transcription. If the mRNA and/or protein number are low, one can observe transcriptional ‘bursts’ in this case provided that the intracellular conditions are steady. Our Monte Carlo simulations show that for biologically reasonable kinetic parameters this effect may easily disappear if the transcription occurs during the cellular growth and division.
Cite:
Zhdanov V.P.
Transient Stochastic Bistable Kinetics of Gene Transcription During the Cellular Growth
Chemical Physics Letters. 2006. V.424. N4-6. P.394-398. DOI: 10.1016/j.cplett.2006.05.024 WOS Scopus РИНЦ
Transient Stochastic Bistable Kinetics of Gene Transcription During the Cellular Growth
Chemical Physics Letters. 2006. V.424. N4-6. P.394-398. DOI: 10.1016/j.cplett.2006.05.024 WOS Scopus РИНЦ
Dates:
Submitted: | Jan 6, 2006 |
Published online: | May 12, 2006 |
Published print: | Jun 24, 2006 |
Identifiers:
Web of science | WOS:000238734200031 |
Scopus | 2-s2.0-33744907520 |
Elibrary | 13511630 |
Chemical Abstracts | 2006:565891 |
Chemical Abstracts (print) | 145:181772 |
OpenAlex | W1967525295 |