Quantum-Chemical Examination of Interaction of Cytostatic-Fluorouracil with Deoxyribonucleic Acids Full article
Journal |
International Journal of Quantum Chemistry
ISSN: 0020-7608 , E-ISSN: 1097-461X |
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Output data | Year: 2007, Volume: 107, Number: 13, Pages: 2384-2388 Pages count : 5 DOI: 10.1002/qua.21340 | ||||
Tags | Antitumoral preparation, Cyclebutane photodimerization, Heteroassociation, Method of quantum chemical | ||||
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Abstract:
Within the framework of semiempirical method of quantum chemical PM3, the possibility of formation of paired stack structures under interaction of fluorouracil with pyrimidine and purine nitrogenous bases of nucleotides has been examined. Possible mechanism of transformation of 2-deoxyuridine-5-monophosphate into metabolite-5-fluorin-2-deoxyuridine-5-monophosphate has been given. The calculations that were made allow to suppose that biotransformation of 5-FU in 5-fluorin-2-deoxyuridine-5-monophosphate, most likely, is carried out not in free nucleotides, but in the structure of DNA in two nucleotide triplets UUC and UGU, including the case when directly two nucleotides of deoxyuridine monophosphate, are transformed into 5-fluorin-2-deoxyuridine-5-monophosphate. Cytostatic ability of 5-FU is increased by its capacity to be selectively embedded into nucleotide triplets creating new chemical compounds that violate matrix RNA formation and accordingly violate protein synthesis.
Cite:
Yuldasheva G.
, Zhidomirov G.M.
Quantum-Chemical Examination of Interaction of Cytostatic-Fluorouracil with Deoxyribonucleic Acids
International Journal of Quantum Chemistry. 2007. V.107. N13. P.2384-2388. DOI: 10.1002/qua.21340 WOS Scopus РИНЦ
Quantum-Chemical Examination of Interaction of Cytostatic-Fluorouracil with Deoxyribonucleic Acids
International Journal of Quantum Chemistry. 2007. V.107. N13. P.2384-2388. DOI: 10.1002/qua.21340 WOS Scopus РИНЦ
Dates:
Submitted: | Dec 13, 2006 |
Accepted: | Feb 15, 2007 |
Published online: | Mar 30, 2007 |
Published print: | Nov 1, 2007 |
Identifiers:
Web of science | WOS:000249459800010 |
Scopus | 2-s2.0-34548557359 |
Elibrary | 13564529 |
Chemical Abstracts | 2007:1069368 |
Chemical Abstracts (print) | 148:25908 |
OpenAlex | W2171473034 |
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