Quantum-Chemical Examination of Interaction of Cytostatic-Fluorouracil with Deoxyribonucleic Acids Научная публикация
Журнал |
International Journal of Quantum Chemistry
ISSN: 0020-7608 , E-ISSN: 1097-461X |
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Вых. Данные | Год: 2007, Том: 107, Номер: 13, Страницы: 2384-2388 Страниц : 5 DOI: 10.1002/qua.21340 | ||||
Ключевые слова | Antitumoral preparation, Cyclebutane photodimerization, Heteroassociation, Method of quantum chemical | ||||
Авторы |
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Организации |
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Реферат:
Within the framework of semiempirical method of quantum chemical PM3, the possibility of formation of paired stack structures under interaction of fluorouracil with pyrimidine and purine nitrogenous bases of nucleotides has been examined. Possible mechanism of transformation of 2-deoxyuridine-5-monophosphate into metabolite-5-fluorin-2-deoxyuridine-5-monophosphate has been given. The calculations that were made allow to suppose that biotransformation of 5-FU in 5-fluorin-2-deoxyuridine-5-monophosphate, most likely, is carried out not in free nucleotides, but in the structure of DNA in two nucleotide triplets UUC and UGU, including the case when directly two nucleotides of deoxyuridine monophosphate, are transformed into 5-fluorin-2-deoxyuridine-5-monophosphate. Cytostatic ability of 5-FU is increased by its capacity to be selectively embedded into nucleotide triplets creating new chemical compounds that violate matrix RNA formation and accordingly violate protein synthesis.
Библиографическая ссылка:
Yuldasheva G.
, Zhidomirov G.M.
Quantum-Chemical Examination of Interaction of Cytostatic-Fluorouracil with Deoxyribonucleic Acids
International Journal of Quantum Chemistry. 2007. V.107. N13. P.2384-2388. DOI: 10.1002/qua.21340 WOS Scopus РИНЦ
Quantum-Chemical Examination of Interaction of Cytostatic-Fluorouracil with Deoxyribonucleic Acids
International Journal of Quantum Chemistry. 2007. V.107. N13. P.2384-2388. DOI: 10.1002/qua.21340 WOS Scopus РИНЦ
Даты:
Поступила в редакцию: | 13 дек. 2006 г. |
Принята к публикации: | 15 февр. 2007 г. |
Опубликована online: | 30 мар. 2007 г. |
Опубликована в печати: | 1 нояб. 2007 г. |
Идентификаторы БД:
Web of science | WOS:000249459800010 |
Scopus | 2-s2.0-34548557359 |
РИНЦ | 13564529 |
Chemical Abstracts | 2007:1069368 |
Chemical Abstracts (print) | 148:25908 |
OpenAlex | W2171473034 |
Цитирование в БД:
Пока нет цитирований