Switches in Gene Expression Including microRNA and a Large Number of Distinct mRNAs Full article
Journal |
Письма в Журнал экспериментальной и теоретической физики
ISSN: 0370-274X |
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Output data | Year: 2008, Volume: 88, Number: 7, Pages: 539-542 Pages count : 4 | ||||
Authors |
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Affiliations |
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Funding (1)
1 | Swedish Research Council |
Abstract:
In eukaryotic cells, the kinetics of gene expression depend on the interplay of messenger RNAs (mRNAs), proteins, and nonprotein coding RNAs, or, more specifically, microRNAs. Some of microRNAs may target hundreds of mRNAs. To describe this case, the author proposes a kinetic model implying that the microRNA synthesis is suppressed by protein produced via translation of one of the target mRNAs. With physically reasonable model parameters, the model predicts bistability or, in other words, switches in expression of hundreds of genes.
Cite:
Zhdanov V.P.
Switches in Gene Expression Including microRNA and a Large Number of Distinct mRNAs
Письма в Журнал экспериментальной и теоретической физики. 2008. V.88. N7. P.539-542. RSCI РИНЦ
Switches in Gene Expression Including microRNA and a Large Number of Distinct mRNAs
Письма в Журнал экспериментальной и теоретической физики. 2008. V.88. N7. P.539-542. RSCI РИНЦ
Translated:
Zhdanov V.P.
Switches in Gene Expression Including microRNA and a Large Number of Distinct mRNAs
Journal of Experimental and Theoretical Physics Letters (JETP Letters). 2008. V.88. N7. P.466-469. DOI: 10.1134/S0021364008190120 WOS Scopus РИНЦ
Switches in Gene Expression Including microRNA and a Large Number of Distinct mRNAs
Journal of Experimental and Theoretical Physics Letters (JETP Letters). 2008. V.88. N7. P.466-469. DOI: 10.1134/S0021364008190120 WOS Scopus РИНЦ
Dates:
Submitted: | Jul 21, 2008 |
Identifiers:
RSCI | RSCI:11709834 |
Elibrary | 11709834 |
Citing:
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