A Minimal Generic Model of Bacteria-Induced Intracellular Ca21 Oscillations in Epithelial Cells Full article
Journal |
Biophysical Journal
ISSN: 0006-3495 , E-ISSN: 1542-0086 |
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Output data | Year: 2005, Volume: 88, Number: 4, Pages: 2976-2981 Pages count : 6 DOI: 10.1529/biophysj.104.053173 | ||||||
Tags | CALCIUM OSCILLATIONS; ALPHA-HEMOLYSIN; DEATH | ||||||
Authors |
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Affiliations |
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Funding (1)
1 | Stiftelsen för strategisk forskning |
Abstract:
The toxin α-hemolysin expressed by uropathogenic Escherichia coli bacteria was recently shown as the first pathophysiologically relevant protein to induce oscillations of the intracellular Ca2+ concentration in target cells. Here, we propose a generic three-variable kinetic model describing the Ca2+ oscillations induced in single rat renal epithelial cells by this toxin. Specifically, we take into account the interplay between 1), the cytosolic Ca2+ concentration; 2), IP3-sensitive Ca2+ channels located in the membrane separating the cytosol and endoplasmic reticulum; and 3), toxin-related activation of production of IP3 by phospholipase C. With these ingredients, the predicted response of cells exposed to the toxin is in good agreement with the results of experiments.
Cite:
Oxhamre C.
, Richter-Dahlfors A.
, Zhdanov V.P.
, Kasemo B.
A Minimal Generic Model of Bacteria-Induced Intracellular Ca21 Oscillations in Epithelial Cells
Biophysical Journal. 2005. V.88. N4. P.2976-2981. DOI: 10.1529/biophysj.104.053173 WOS Scopus РИНЦ
A Minimal Generic Model of Bacteria-Induced Intracellular Ca21 Oscillations in Epithelial Cells
Biophysical Journal. 2005. V.88. N4. P.2976-2981. DOI: 10.1529/biophysj.104.053173 WOS Scopus РИНЦ
Files:
Full text from publisher
Dates:
Submitted: | Sep 17, 2004 |
Accepted: | Nov 19, 2004 |
Published print: | Apr 1, 2005 |
Published online: | Jan 6, 2009 |
Identifiers:
Web of science | WOS:000227986300055 |
Scopus | 2-s2.0-22144462395 |
Elibrary | 13499058 |
Chemical Abstracts | 2005:314068 |
Chemical Abstracts (print) | 142:425179 |
OpenAlex | W2041384310 |