The Role of Fluids in High-Pressure Polymorphism of Drugs: Different Behaviour of β-Chlorpropamide in Different Inert Gas and Liquid Media Full article
| Journal |
RSC Advances
ISSN: 2046-2069 |
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| Output data | Year: 2016, Volume: 6, Number: 95, Pages: 92629-92637 Pages count : 9 DOI: 10.1039/c6ra17750f | ||||||||||||||
| Tags | Paraffins, Ambient pressures, High pressure polymorphism, High-pressure phasis, Hydrostatic compression, Liquid media, Pentane isopentane, Inert gases | ||||||||||||||
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Abstract:
The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.
Cite:
Zakharov B.A.
, Seryotkin Y.V.
, Tumanov N.A.
, Paliwoda D.
, Hanfland M.
, Kurnosov A.V.
, Boldyreva E.V.
The Role of Fluids in High-Pressure Polymorphism of Drugs: Different Behaviour of β-Chlorpropamide in Different Inert Gas and Liquid Media
RSC Advances. 2016.
V.6. N95. P.92629-92637. DOI: 10.1039/c6ra17750f
WOS
Scopus
РИНЦ
OpenAlex
AN
The Role of Fluids in High-Pressure Polymorphism of Drugs: Different Behaviour of β-Chlorpropamide in Different Inert Gas and Liquid Media
RSC Advances. 2016.
V.6. N95. P.92629-92637. DOI: 10.1039/c6ra17750f
WOS
Scopus
РИНЦ
OpenAlex
AN
Files:
Full text from publisher
Dates:
| Submitted: | Jul 12, 2016 |
| Accepted: | Sep 21, 2016 |
| Published online: | Sep 21, 2016 |
Identifiers:
| ≡ Web of science: | WOS:000385389800057 |
| ≡ Scopus: | 2-s2.0-84989318889 |
| ≡ Elibrary: | 27570815 |
| ≡ OpenAlex: | W2523564795 |
| ≡ Chemical Abstracts: | 2016:1539080 |