Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation Full article
| Journal |
Analytical Chemistry
ISSN: 0003-2700 , E-ISSN: 1520-6882 |
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| Output data | Year: 2022, Volume: 94, Number: 43, Pages: 15010-15017 Pages count : 8 DOI: 10.1021/acs.analchem.2c02929, 10.26434/chemrxiv-2022-dp639 | ||||||||||||
| Tags | through space multinuclear magnetic resonance signal enhancement parahydrogen; radio frequency amplification stimulated emission radiation; hyperpolarized nuclear spin | ||||||||||||
| Authors |
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| Affiliations |
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Funding (19)
| 1 | Council for Grants of the President of the Russian Federation | МК-2826.2022.1.3 |
| 2 | Russian Foundation for Basic Research | 19-33-60045 |
| 3 | Russian Science Foundation | 21-73-10105 (121121600301-4) |
| 4 | Federal Ministry of Education and Research | 01ZX1915C |
| 5 | United States Department of Defense | W81XWH-20-10576 |
| 6 | National Institute of Biomedical Imaging and Bioengineering | 1R01EB029829 |
| 7 | National Institutes of Health | 1R21HL154032-01 |
| 8 | German Research Foundation | GRK 2154/1-2019 |
| 9 | European Commission | 122-09-053 |
| 10 | National Science Foundation | CHE-1904780 |
| 11 | National Institutes of Health | 1R21CA220137 |
| 12 | German Research Foundation | HO 4602/3 |
| 13 | German Research Foundation | HO 4602/2-2 |
| 14 | German Research Foundation | PR1868/3-1 |
| 15 | German Research Foundation | EXC2167 |
| 16 | German Research Foundation | FOR5042 |
| 17 | German Research Foundation | TRR287 |
| 18 | German Research Foundation | SFB 1479 |
| 19 | Ministry of Science and Higher Education of the Russian Federation |
Abstract:
Hyperpolarized (i.e., polarized far beyond the thermal equilibrium) nuclear spins can result in the radiofrequency amplification by stimulated emission of radiation (RASER) effect. Here, we show the utility of RASER to amplify nuclear magnetic resonance (NMR) signals of solute and solvent molecules in the liquid state. Specifically, parahydrogen-induced RASER was used to spontaneously enhance nuclear spin polarization of protons and heteronuclei (here 19F and 31P) in a wide range of molecules. The magnitude of the effect correlates with the T1 relaxation time of the target nuclear spins. A series of control experiments validate the through-space dipolar mechanism of the RASER-assisted polarization transfer between the parahydrogen-polarized compound and to-be-hyperpolarized nuclei of the target molecule. Frequency-selective saturation of the RASER-active resonances was used to control the RASER and the amplitude of spontaneous polarization transfer. Spin dynamics simulations support our experimental RASER studies. The enhanced NMR sensitivity may benefit various NMR applications such as mixture analysis, metabolomics, and structure determination.
Cite:
Salnikov O.G.
, Trofimov I.A.
, Pravdivtsev A.N.
, Them K.
, Hövener J-B.
, Chekmenev E.Y.
, Koptyug I.V.
Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation
Analytical Chemistry. 2022. V.94. N43. P.15010-15017. DOI: 10.1021/acs.analchem.2c02929, 10.26434/chemrxiv-2022-dp639 WOS Scopus РИНЦ AN PMID OpenAlex
Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation
Analytical Chemistry. 2022. V.94. N43. P.15010-15017. DOI: 10.1021/acs.analchem.2c02929, 10.26434/chemrxiv-2022-dp639 WOS Scopus РИНЦ AN PMID OpenAlex
Dates:
| Submitted: | Jul 7, 2022 |
| Accepted: | Oct 7, 2022 |
| Published online: | Oct 20, 2022 |
| Published print: | Nov 1, 2022 |
Identifiers:
| Web of science: | WOS:000888011300001 |
| Scopus: | 2-s2.0-85141743110 |
| Elibrary: | 54731934 |
| Chemical Abstracts: | 2022:2663707 |
| PMID: | 36264746 |
| OpenAlex: | W4306893554 |