Direct Selective Azidation of C(sp3)−H Groups Review
| Journal |
Tetrahedron Chem
ISSN: 2666-951X |
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| Output data | Year: 2024, Volume: 12, Article number : 100114, Pages count : 21 DOI: 10.1016/j.tchem.2024.100114 | ||||
| Tags | azidation, C−H activation; homogeneous catalysis; late-stage functionalization; mechanism | ||||
| Authors |
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| Affiliations |
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Funding (1)
| 1 | Ministry of Science and Higher Education of the Russian Federation | FWUR-2024-0032 |
Abstract:
Organic azides are convenient and versatile intermediates for the synthesis of various nitrogen-containing scaffolds, including biologically active compounds, approved drugs, functional materials, etc. Designing general approaches to deliberately chemo-, regio-, and steroselective synthesis of aliphatic azides is an urgent task of synthetic chemistry. Particularly challenging is direct azidation of non-activated C(sp3)−H groups, capable of providing ready access to remote and late-stage functionalization of complex targets without need for re-designing existing multistep synthetic procedures. This contribution surveys the existing C(sp3)−H azidation approaches, including catalytic and enzyme-mediated ones, with major focus on the coordination chemistry aspects and synthetic perspective of these transformations. Essential mechanistic details are briefly discussed.
Cite:
Antonov A.A.
, Bryliakov K.P.
Direct Selective Azidation of C(sp3)−H Groups
Tetrahedron Chem. 2024. V.12. 100114 :1-21. DOI: 10.1016/j.tchem.2024.100114 Scopus AN OpenAlex
Direct Selective Azidation of C(sp3)−H Groups
Tetrahedron Chem. 2024. V.12. 100114 :1-21. DOI: 10.1016/j.tchem.2024.100114 Scopus AN OpenAlex
Dates:
| Submitted: | Oct 11, 2024 |
| Accepted: | Nov 24, 2024 |
| Published online: | Nov 26, 2024 |
| Published print: | Dec 1, 2024 |
Identifiers:
| Scopus: | 2-s2.0-85210292039 |
| Chemical Abstracts: | 2024:2656863 |
| OpenAlex: | W4404725856 |
Citing:
| DB | Citing |
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| Scopus | 1 |