Chemical Exchange Reaction Effect on Polarization Transfer Efficiency in SLIC-SABRE
Научная публикация
| Общее |
Язык:
Английский,
Жанр:
Статья (Full article),
Статус опубликования:
Опубликована,
Оригинальность:
Оригинальная
|
| Журнал |
The Journal of Physical Chemistry A
ISSN: 1089-5639
, E-ISSN: 1520-5215
|
| Вых. Данные |
Год: 2018,
Том: 122,
Номер: 46,
Страницы: 9107-9114
Страниц
: 8
DOI:
10.1021/acs.jpca.8b07163
|
| Ключевые слова |
Polarization |
| Авторы |
Pravdivtsev Andrey N.
1
,
Skovpin Ivan V.
2,3
,
Svyatova Alexandra I.
2,3
,
Chukanov Nikita V.
2,3
,
Kovtunova Larisa M.
3,4
,
Bukhtiyarov Valerii I.
4
,
Chekmenev Eduard Y.
5,6
,
Kovtunov Kirill V.
2,3
,
Koptyug Igor V.
2,3
,
Hövener Jan-Bernd
1
|
| Организации |
| 1 |
Section for Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein (UKSH), Kiel University, Am Botanischen Garten 14, 24118 Kiel, Germany
|
| 2 |
International Tomography Center, Siberian Branch of the Russian Academy of the Sciences, Institutskaya st. 3 A, 630090 Novosibirsk, Russia
|
| 3 |
Novosibirsk State University, Pirogova st. 2, 630090 Novosibirsk, Russia
|
| 4 |
Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of the Sciences, 5 Acad. Lavrentiev Ave., 630090 Novosibirsk, Russia
|
| 5 |
Department of Chemistry, Wayne State University, Karmanos Cancer Institute (KCI), Integrative Biosciences (Ibio), Detroit, Michigan 48202, United States
|
| 6 |
Russian Academy of Sciences, Leninskiy Prospekt 14, 119991 Moscow, Russia
|
|
Информация о финансировании (11)
|
1
|
National Institutes of Health
|
1R21EB020323
|
|
2
|
National Science Foundation
|
CHE-1416268
|
|
3
|
United States Department of Defense
|
W81XWH-12-1-0159/BC112431
|
|
4
|
United States Department of Defense
|
W81XWH-15-1-0271
|
|
5
|
Российский научный фонд
|
17-73-20030
|
|
6
|
Российский фонд фундаментальных исследований
|
16-33-60198
|
|
7
|
Федеральное агентство научных организаций России
|
0333-2017-0002
|
|
8
|
National Institutes of Health
|
1R21CA220137
|
|
9
|
German Research Foundation
|
HO 4604/2-1
|
|
10
|
National Science Foundation
|
CHE-1836308
|
|
11
|
European Commission
|
122-09-053
|
Signal Amplification By Reversible Exchange (SABRE) is a new and rapidly developing hyperpolarization technique. The recent discovery of Spin-Lock Induced Crossing SABRE (SLIC-SABRE) showed that high field hyperpolarization transfer techniques developed so far were optimized for singlet spin order that does not coincide with the experimentally produced spin state. Here, we investigated the SLIC-SABRE approach and the most advanced quantitative theoretical SABRE model to date. Our goal is to achieve the highest possible polarization with SLIC-SABRE at high field using the standard SABRE system, IrIMes catalyst with pyridine. We demonstrated the accuracy of the SABRE model describing the effects of various physical parameters such as the amplitude and frequency of the radio frequency field, and the effects of chemical parameters such as the exchange rate constants. By fitting the model to the experimental data, the effective life time of the SABRE complex was estimated, as well as the entropy and enthalpy of the complex-dissociation reaction. We show, for the first time, that this SLIC-SABRE model can be useful for the evaluation of the chemical exchange parameters that are very important for the production of highly polarized contrast agents via SABRE.