Nasal Aerodynamics Protects Brain and Lung from Inhaled Dust in Subterranean Diggers, Ellobius Talpinus Научная публикация
Журнал |
Proceedings of The Royal Society B - Biological Sciences
ISSN: 0962-8452 , E-ISSN: 1471-2954 |
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Вых. Данные | Год: 2014, Том: 281, Номер: 1792, Страницы: 20140919 Страниц : 6 DOI: 10.1098/rspb.2014.0919 | ||||||||||||||||
Ключевые слова | Adaptation to dust, Ellobius, Mus, Nanoparticles, Nasal aerodynamics, Subterranean rodents | ||||||||||||||||
Авторы |
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Организации |
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Информация о финансировании (6)
1 | Российский научный фонд | 14-14-00221 |
2 | Сибирское отделение Российской академии наук | 57 |
3 | Сибирское отделение Российской академии наук | 60 |
4 | Сибирское отделение Российской академии наук | 61 |
5 | Сибирское отделение Российской академии наук | 122 |
6 | Сибирское отделение Российской академии наук | 108 |
Реферат:
Inhalation of air-dispersed sub-micrometre and nano-sized particles presents a risk factor for animal and human health. Here, we show that nasal aerodynamics plays a pivotal role in the protection of the subterranean mole vole Ellobius talpinus from an increased exposure to nano-aerosols. Quantitative simulation of particle flow has shown that their deposition on the total surface of the nasal cavity is higher in the mole vole than in a terrestrial rodent Mus musculus (mouse), but lower on the olfactory epithelium. In agreement with simulation results, we found a reduced accumulation of manganese in olfactory bulbs of mole voles in comparison with mice after the inhalation of nano-sized MnCl2 aerosols. We ruled out the possibility that this reduction is owing to a lower transportation from epithelium to brain in the mole vole as intranasal instillations of MnCl2 solution and hydrated nanoparticles of manganese oxide MnO · (H2O)x revealed similar uptake rates for both species. Together, we conclude that nasal geometry contributes to the protection of brain and lung from accumulation of air-dispersed particles in mole voles.
Библиографическая ссылка:
Moshkin M.P.
, Petrovski D.V.
, Akulov A.E.
, Romashchenko A.V.
, Gerlinskaya L.A.
, Ganimedov V.L.
, Muchnaya M.I.
, Sadovsky A.S.
, Koptyug I.V.
, Savelov A.A.
, Troitsky S.Y.
, Moshkin Y.M.
, Bukhtiyarov V.I.
, Kolchanov N.A.
, Sagdeev R.Z.
, Fomin V.M.
Nasal Aerodynamics Protects Brain and Lung from Inhaled Dust in Subterranean Diggers, Ellobius Talpinus
Proceedings of The Royal Society B - Biological Sciences. 2014. V.281. N1792. P.20140919. DOI: 10.1098/rspb.2014.0919 WOS Scopus РИНЦ РИНЦ
Nasal Aerodynamics Protects Brain and Lung from Inhaled Dust in Subterranean Diggers, Ellobius Talpinus
Proceedings of The Royal Society B - Biological Sciences. 2014. V.281. N1792. P.20140919. DOI: 10.1098/rspb.2014.0919 WOS Scopus РИНЦ РИНЦ
Файлы:
Полный текст от издателя
Даты:
Поступила в редакцию: | 17 апр. 2014 г. |
Принята к публикации: | 23 июл. 2014 г. |
Опубликована online: | 20 авг. 2014 г. |
Опубликована в печати: | 7 окт. 2014 г. |
Идентификаторы БД:
Web of science | WOS:000341095900008 |
Scopus | 2-s2.0-85006257538 |
РИНЦ | 23983828 , 41767099 |
PMID (PubMed) | 25143031 |
OpenAlex | W1972091988 |